Method of manufacturing polyamino acid with microwaves

• US 4,696,981 A
• Filed: 03/13/1986
• Issued: 09/29/1987
• Est. Priority Date: 03/25/1985
• Status: Expired due to Fees

• Current Assignee: Kaoru Harada, Diamond Shamrock Chemicals Co (Valero Energy Corporation)
• Original Assignee: Diamond Shamrock Chemicals Co (Valero Energy Corporation)
• Inventors: Shimoyama, Akira, Harada, Kaoru, Mizumoto, Hiroji
• Primary Examiner(s): ANDERSON, HAROLD
• Application Number:
  US06/839,353
• Time in Patent Office: 565 Days
• Field of Search: 528/328, 528/271, 528/361, 528/367, 526/303.1, 526/304, 526/306, 526/307, 526/307.3, 526/307.4, 526/311, 526/312, 526/922, 526/923, 525/328.2, 525/328.4, 525/420, 525/421
• US Class Current: 522/176
• CPC Class Codes: C08G 69/10 Alpha-amino-carboxylic acids polysuccinimides C08G73/1092
• CPC Class Codes: Y10S 526/922 Polymerization process of ethylenic monomers using manipulative technique
• CPC Class Codes: Y10S 526/923 Ethylenic monomers containing at least one salt group

Abstract

Homopolyamino acids and copolyamino acids are prepared by polycondensation of one kind or a mixture of two or more kinds of monoammonium, diammonium, monoamide, diamide or monoamideammonium salts of malic acid and/or maleic acid and/or fumaric acid, one kind or two or more kinds of amino acid being added to said raw materials, respectively, with application of microwaves, the resulting polyamino acids (imide type) being converted to peptide type, homopolyamino acids and copolyamino acids, respectively upon partial hydrolysis. The operation involved in the reaction is simple and the method permits the use of low cost reaction materials. As a result, imide type and also peptide type, homopolyamino and copolyamino acids are produced with uniform quality at a high rate of yield within an extremely short period of time. Accordingly, the method is incomparably superior to those which have been announced in the past.

Claims

1. A method of manufacturing anhydropolyaspartic acid (imide) by irradiating with microwaves, any one member selected from the group consisting of monoammonium, diammonium, monoamide, diamide and monoamideammonium salts of malic acid, maleic acid fumaric acid and mixtures thereof.

2. The method of claim 1 wherein the resulting anhydropolyaspartic acid (imide) is further partially hydrolyzed to form polyaspartic acid (peptide).

3. The method of claim 1 wherein one member to be irradiated with microwaves is selected from the group consisting of malic acid monoammonium salt, maleic acid monoammonium salt and ammonium salt of maleamic acid.

4. The method of claim 2 wherein one member to be irradiated with microwaves is selected from the group consisting of malic acid monoamminium salt, maleic acid monoammonium salt and ammonium salt of maleamic acid.

5. A method of manufacturing copolyamino acid (imide) by irradiating with microwaves, any one member selected from the group consisting of monoammonium, diammonium, monoamide, diamide and monoamideammonium salts of malic acid, maleic acid, fumaric acid and mixtures thereof, with the addition of at least one amino acid.

6. The method of claim 5 wherein the resulting copolyamino acid (imide) is further partially hydrolyzed to form copolyamino acid (peptide).

7. The method of claim 5 wherein one member to be irradiated with microwaves is selected from the group consisting of malic acid monoammonium salt, maleic acid monoammonium salt and ammonium salt of maleamic acid.

8. The method of claim 6 wherein one member to be irradiated with microwaves is selected from the group consisting of malic acid monoammonium salt, maleic acid monoammonium salt and ammonium salt of maleamic acid.

9. The method of claim 5 wherein the amino acid is selected from the group consisting of α

-amino acids, β

-amino acids, γ

-amino acids, δ

-amino acids and ε

-amino acids.

10. The method of claim 6 wherein the amino acid is selected from the group consisting of α

-amino acids, β

-amino acids, γ

-amino acids, δ

-amino acids and ε

-amino acids.

11. The method of claim 5 wherein the amino acid is selected from the group consisting of glycin, alanine, leucine, isoleucine, methionine, lysine, valline, glutamic acid and β

-alanine.

12. The method of claim 6 wherein the amino acid is selected from the group consisting of glycin, alanine, leucine, isoleucine, methionine, lysine, valline, glutamic acid and β

-alanine.