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Medical device for pulsatile transdermal delivery of biologically active agents

  • US 4,698,062 A
  • Filed: 10/30/1985
  • Issued: 10/06/1987
  • Est. Priority Date: 10/30/1985
  • Status: Expired due to Fees
First Claim
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1. A medical device for the pulsitile administration of a drug through intact skin at a first steady state flux during a first delivery period and a second steady state flux during a second delivery period, said first and second delivery periods comprising a substantial portion of a predetermined administration period;

  • said device comprising;

    (a) a reservoir of said drug containing an amount of drug at least sufficient to administer drug at said first and second steady state fluxes throughout said administration period, said first steady state flux being substantially higher than said second steady states flux(b) a reservoir of a skin permeation enhancer for said drug;

    said reservoir containing an amount of permeation enhancer (i) sufficient to permit administration of said permeation enhancer at permeation enhancing fluxes through said first delivery period and (ii) insufficient to permit administration of said permeation enhancer at permeation enhancing fluxes during the remainder of said administration period; and

    (c) means for maintaining said device on the skin in drug and permeation enhancer transferring relationship thereto;

    whereby a pulsitile drug administration pattern, having a first flux substantially higher than the flux of drug through untreated skin during said first period and a second, substantially lower flux during said second delivery period, will be obtained.

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