Neurocybernetic prosthesis

• US 4,702,254 A
• Filed: 12/30/1985
• Issued: 10/27/1987
• Est. Priority Date: 09/14/1983
• Status: Expired due to Term

• Current Assignee: Jacob Zabara
• Original Assignee: Jacob Zabara
• Inventors: Zabara, Jacob
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US06/814,846
• Time in Patent Office: 666 Days
• Field of Search: 128/419 C, 128/419 E, 128/419 R, 128/421, 128/422, 128/423 R
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36157 Current A61N1/3616 takes precedence
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators

Abstract

A neurocybernetic prosthesis for controlling or preventing epileptic seizures and other motor disorders includes a pulse generator which generates electrical pulses having a frequency of between 30 and 300 cycles per second, a pulse duration of between 0.3 and 1 millisecond and a constant current of between 1 and 20 milliamperes. The generator is enclosed in an epoxy-titanium shell and is implanted in the body, preferably in the axilla. Electrode leads pass from the generator through a subcutaneous tunnel and terminate in an electrode patch on the vagus nerve. Provisions are made for varying the electrical signal from the generator after it has been implanted to "tune" the same to the patient. The prosthesis may be designed to be turned on manually when the patient senses the imminence of a convulsion. Alternatively, sensors may be provided for determining changes in the values of state parameters such as electrocencephalographic waves which precede a convulsion. The pulse generator can then be turned on automatically in response to the sensors.

Claims

1. A method of controlling or preventing involuntary movements such as caused by epileptic seizures, cerebral palsy, Parkinson'"'"'s disease, spasticity, motor disorders and the like comprising determining that an involuntary movement is going to occur and thereafter applying a pulsed electrical signal to the vagus nerve to thereby prevent or control such movement.

2. The method of claim 1 wherein the electrical signal has a pulse frequency of approximately between 30 and 300 cycles per second and wherein each pulse has a duration of between 0.3 and 1 millisecond and substantially constant current of between approximately 1 and 20 milliamperes.

3. The method of claim 1 wherein the signal is applied utilizing a plurality of electrodes.

4. The method of claim 3 wherein there is a negative electrode and a positive electrode and wherein the negative electrode is applied proximal to the brain and the positive electrode is applied distal thereto.

5. The method of claim 3 wherein there is a negative electrode and a positive electrode and wherein the negative electrode is placed in the vicinity of the vagus nerve and the positive electrode is applied to a remote part of the body.

6. The method of claim 1 wherein said signal is applied in such a way as to avoid any substantial slowing of the heart rate.

7. The method of claim 1 including the step of repeatedly applying said signal over a period of time.

8. A neurocybernetic prosthesis for controlling or preventing involuntary movements such as caused by epileptic seizures, cerebral palsy, Parkinson'"'"'s disease, spasticity, motor disorders and the like comprising:

an electrical pulse generator capable of generating pulses having a frequency of approximately between 30 and 300 cycles per second with each pulse having a duration of between approximately 0.3 and 1 millisecond;

a positive electrode adapted to be applied to a person'"'"'s body and means electrically connecting said electrode to said pulse generator;

a negative electrode adapted to be applied to a person'"'"'s body adjacent the vagus nerve and means for electrically connecting said electrode to said generator;

means for sensing electroencephalographic waves and means responsive to a predetermined change in the sensed electroencephalographic waves for turning said pulse generator on.

9. The invention of claim 8 wherein said pulse generator is enclosed in a shell so that the same may be implanted in the person'"'"'s body.

10. The invention of claim 9 including means for manually turning said generator on when the same is implanted.

11. The invention of claim 9 including means for varying the electrical signal generated by said generator from outside a person'"'"'s body when the generator is implanted.

12. A method of controlling or preventing involuntary movements such as caused by epileptic seizures, cerebral palsy, Parkinson'"'"'s disease, spasticity, motor disorders and the like comprising determining that an involuntary movement is going to occur and thereafter applying a pulsed electrical signal to the vagus nerve at a point below the inferior cardiac nerve to thereby prevent or control such movement.

13. The method of claim 12 wherein the electrical signal has a pulse frequency of approximately between 30 and 300 cycles per second and wherein each pulse has a duration of between 0.3 and 1 millisecond and substantially constant current of between approximately 1 and 20 milliamperes.

14. The method of claim 12 wherein the signal is applied utilizing a plurality of electrodes.

15. The method of claim 14 wherein there is a negative electrode and a positive electrode and wherein the negative electrode is applied proximal to the brain and the positive electrode is applied distal thereto.

16. The method of claim 14 wherein there is a negative electrode and a positive electrode and wherein the negative electrode is placed in the vicinity of the vagus nerve and the positive electrode is applied to a remote part of the body.

17. The method of claim 12 including the step of repeatedly applying said signal over a period of time.