Complete glucose monitoring system with an implantable, telemetered sensor module
First Claim
1. An electrochemical system implantable into a body for detecting glucose and oxygen levels in fluids or tissues therein and capable of transmitting information about said glucose and oxygen levels outside said body, comprising:
- an elongate housing implantable in a body, said housing having a tip and being permeable to oxygen along its length;
first and second oxygen sensor means for measuring an oxygen content differential in bodily fluids or tissues, said first and second oxygen sensor means disposed in tandem in said housing in a discontinous, spaced-apart relationship. said first and second oxygen sensor means recessed in said housing from said tip. said first oxygen sensor means being unaltered and said second oxygen sensor means contacting glucose oxidase for oxidation of glucose;
implantable electronic circuit means responsive to said first and second oxygen sensor means for providing a signal indicative of an oxygen content differential in said fluids or tissues;
telemetry means for communicating said signal from the interior to the exterior of said body; and
an external processing means outside of said body and responsive to said telemetry means for converting said oxygen content differential to glucose level indications.
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Accused Products
Abstract
An electrochemical system includes a sensor module suitable for implantation in the body to monitor glucose and oxygen levels therein. The module has two oxygen sensors situated in an oxygen-permeable housing, arranged in a tandem relationship, and recessed in the housing, one sensor being unaltered and the other contacting glucose oxidase allowing for differential measurement of oxygen content in bodily fluids or tissues indicative of glucose levels. The module includes a communication capability for transmitting measurement information to an external recording device outside the body.
1547 Citations
23 Claims
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1. An electrochemical system implantable into a body for detecting glucose and oxygen levels in fluids or tissues therein and capable of transmitting information about said glucose and oxygen levels outside said body, comprising:
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an elongate housing implantable in a body, said housing having a tip and being permeable to oxygen along its length; first and second oxygen sensor means for measuring an oxygen content differential in bodily fluids or tissues, said first and second oxygen sensor means disposed in tandem in said housing in a discontinous, spaced-apart relationship. said first and second oxygen sensor means recessed in said housing from said tip. said first oxygen sensor means being unaltered and said second oxygen sensor means contacting glucose oxidase for oxidation of glucose; implantable electronic circuit means responsive to said first and second oxygen sensor means for providing a signal indicative of an oxygen content differential in said fluids or tissues; telemetry means for communicating said signal from the interior to the exterior of said body; and an external processing means outside of said body and responsive to said telemetry means for converting said oxygen content differential to glucose level indications. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An implantable electrochemical sensor, comprising:
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an elongate housing, permeable to oxygen along its length, having a tip, and implantable in human tissue; and first and second oxygen sensor means for measuring an oxygen content differential in bodily fluids or tissues, said first and second oxygen sensor means disposed in tandem in said housing in a discontinuous, spaced-apart relationship, said first and second oxygen sensor means recessed in said housing from said tip, said first oxygen sensor means being unaltered and said second oxygen sensor means contacting glucose oxidase for oxidation of glucose. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification