Blood sampling device for obtaining small quantity of venous blood

• US 4,703,761 A
• Filed: 08/04/1986
• Issued: 11/03/1987
• Est. Priority Date: 08/04/1986
• Status: Expired due to Fees

• Current Assignee: Robert A. Levine, William W. Jones
• Original Assignee: William W. Jones
• Inventors: Wardlaw, Stephen C., Rathbone, R. Rodion
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Hindenburg, Max F.
• Application Number:
  US06/892,265
• Time in Patent Office: 456 Days
• Field of Search: 128/763-768, 128/770, 604/126, 604/167, 604/215, 604/236-238, 604/264, 604/272, 604/403, 604/406, 604/410, 604/411, 604/414
• US Class Current: 600/576
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150213 Venting means
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150251 Collection chamber divided into at least two compartments, e.g. for division of samples injection syringes having more than one chamber A61M5/19; syringes for injection of two or more media A61M5/2448, A61M5/284; sample preparation for further analysis A61B5/150755
• CPC Class Codes: A61B 5/150305 Packages specially adapted for piercing devices or blood sampling devices kits for diabetes A61M5/003; packaging in general B65D
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/150717 manually removed
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150786 Optical identification systems, e.g. bar codes, colour codes
• CPC Class Codes: A61B 5/150885 Preventing re-use
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: B01L 2300/0838 Capillaries
• CPC Class Codes: B01L 2300/087 Multiple sequential chambers
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 3/505 flexible containers not provided for above

Abstract

This device is adapted for taking venous blood samples without the aid of any auxiliary negative pressure. Venous blood pressure is the sole force which fills the device with the blood sample. The device includes a flexible plastic tube formed from polyethylene or the like and further includes a blood drawing needle mounted on one end of the tube. The tube is divided into a collection reservoir into which the sample is drawn, and a sampling reservoir into which the sample may be expressed from the collection area. A valve separates the two areas. Also included in an elastomeric needle closure which adapts the device for in situ centrifugation of the blood sample in a test tube.

Claims

1. A device for utilizing venous blood pressure for drawing a blood sample, said device comprising:

(a) a first tublar body providing a first collection reservoir for receiving the blood sample.

(b) a needle mounted on one end of said tublar body for drawing the blood sample into said collection reservoir;

(c) first valve means on the opposite end of said tubular body, said first valve means including a hydrophobic porous portion to allow flow of air from said collection reservior through said first valve means while blocking flow of blood from said collection reservoir through said first valve means, and said first valve means further including a passage formed in situ adjacent said hydrophobic porous portion which passage is operable to allow flow of blood from said collection reservoir through said first valve means; and

(d) closure means for selectively closing said passage when a blood sample is drawn into said first collection reservoir through said needle.

2. The device of claim 1 wherein said tubular body further includes an integral sampling reservoir and said valve means is interposed between said collection reservoir and said sampling reservoir.

3. The device of claim 2 wherein said tubular body is elastomeric and said closure means is formed by a kink in said tubular body and said hydrophobic material is positioned in said kink.

4. The device of claim 3 wherein said hydrophobic material is in the form of an annular body having a through bore through which blood can flow when said kink is open.

5. The device of claim 3 further comprising a plug for sealing said needle after a blood sample is drawn.

6. The device of claim 5 wherein said tubular body includes a rigid base part secured thereto at the needle end thereof, and said plug and base part include interlocking means for locking said plug in needle-sealing engagement with said base part.

7. The device of claim 1 further comprising a second tubular body side-by-side and integral with said first tubular body, said second tubular body providing a second collection reservoir, and said second tubular body including second valve means operable in the same manner as said first valve means, and a blood flow passage connecting said first and second collection reservoir such that blood will flow into said second collection reservoir after said first collection reservoir is filled with blood.

8. A device for drawing a sample of blood solely by venous blood pressure, said device comprising:

(a) an elastomeric tubular member forming a blood collection reservoir and an adjacent blood sampling reservoir;

valve mens interposed between said collection reservoir and said sampling reservoir, said valve means including an air permeable portion and an in situ blood passage, and said valve means being operable, when said blood passage is closed, to allow flow of air while blocking flow of blood from said collection reservoir to said sampling reservoir through said valve means, and operable when said blood passage is open, to allow flow of blood from said collection reservoir to said sampling reservoir; and

(c) a blood drawing needle mounted at the end of said collection reservoir remote from said valve means for drawing blood into said collection reservoir.

9. The device of claim 8 wherein said valve means includes a kink in said tubular member and an annular body of a hydrophobic material positioned in said tubular member in said kink, said kink being formed to close said valve means by bending said tubular member so as to position said sampling reservoir side-by-side with said collection reservoir and wherein said valve means is opened by pivoting said sampling reservoir about said kink away from said collection reservoir.

10. The device of claim 8 further comprising an elastomeric plug for embedment of said needle to seal said needle after a blood sample is drawn to prevent blood from being expressed from said collection reservoir through said needle and to provide said valve means as the sole means for enabling blood to be removed from said collection reservoir.

11. The device of claim 10 wherein said plug has a rounded outer end surface to adapt said device to be positioned in a centrifuge tube to enable in situ centrifugation of a blood sample in said collection reservoir.

12. The device of claim 10 further including means for irreversably locking said plug to said tubular member in sealing engagement with said needle.

13. A device for drawing a sample of blood solely by venous blood pressure, said device comprising:

(a) an elastomeric tubular member forming a blood collection reservoir and an adjacent blood sampling reservoir;

(b) a sleeve of hydrophobic material disposed in said tubular member between said reservoirs, said sleeve having a through bore forming a passage between said reservoirs;

(c) a blood drawing needle disposed at an end of said collection reservoir remote from said sleeve, said needle providing means for drawing blood into said collection reservoir;

(d) said tubular member being bent upon itself to position said sampling reservoir side-by-side with said collection reservoir and to form a kink in said tubular member and said sleeve to close said passage between said reservoirs, whereby said sleeve allows flow of air from said collection reservoir to said sampling reservoir during the drawing of a blood sample but blocks flow of blood from said collection reservoir to said sampling reservoir; and

(e) said passage being operable to allow blood to pass therethrough by manipulating said tubular member to remove said kink.

14. The device of claim 13 further comprising an elastomeric plug for sealing said needle after a blood sample is drawn to prevent blood from being expressed from said collection reservoir via said needle whereby blood can only be removed from said collection reservoir through said passage.

15. The device of claim 14 wherein said tubular member and said elastomeric plug are provided with interlocking means to prevent said plug from being removed from said needle after engagement of said interlocking means.

16. The device of claim 14 wherein said plug has a rounded outer end surface to adapt said device for positioning in a centrifuge tube to enable in situ centrifugation of the blood sample in said collection reservoir.

17. The device of claim 13 further including means for releasably holding said sampling reservoir in side-by-side relationship with said collection reservoir.

18. In a blood sampling device, a valve comprising:

an outer elastomeric tube which is impervious to both air and blood, and an inner sleeve formed from a hydrophobic material pervious to air but impervious to blood, said inner sleeve including a central through passage, said valve being closable to the passage of blood while allowing the passage of air by binding said outer tube and said inner sleeve sufficiently to form a kink in said tube and sleeve which closes said through passage, and said valve being openable to the passage of blood by unbending said tube and sleeve sufficiently to eliminate said kink and open said through passage.

19. A device for drawing a plurality of blood samples with a single venapuncture solely by venous blood pressure, said device comprising:

(a) a first tubular molded plastic member forming a first blood collection reservoir;

(b) a second tubular molded plastic member forming a second blood collection reservoir;

(c) a molded plastic web integral with said first and second tubular members and interconnecting the latter so that said tubular members are disposed in side-by-side relationship;

(d) vent means at one end of each of said collection reservoirs for venting air from said reservoirs during drawing of a blood sample, said vent means being operable to prevent the flow of blood therethrough;

(e) a blood drawing needle at the end of said first collection reservoir opposite said vent means for drawing a blood sample into said first collection reservoir; and

(f) a transverse passage extending through said web from said first collection reservoir to said second collection reservoir to provide means for transferring blood from said first collection reservoir to said second collection reservoir.

20. The device of claim 19 wherein said first and second plastic members each are formed with a common flat surface, and said device is folded about said web to bring said flat surfaces into face-to-face relationship to close said transverse passage after blood samples have been drawn into said first and second collection reservoirs.