Ruminant dispensing device with thermo-activated memory
First Claim
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1. A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising:
- (a) wall means for surrounding and forming an internal space;
(b) means in the wall connecting the internal space with the exterior of the dispensing device for releasing beneficial agent from the device;
(c) carrier means in the internal space for containing a beneficial agent and for forming a dispensable beneficial agent formulation in the dispensing device when the dispensing device is in the environment of use;
(d) a beneficial agent present in the carrier means;
(e) expandable means in the internal space for moving from a rested position to an expanded position for occupying an increasing area of the internal space thereby urging the beneficial agent formulation through the means for releasing beneficial agent over time; and
,(f) weight means contained in the expandable means, said weight means possessing a density of at least 1.0 for increasing the density of the dispensing device, thereby maintaining the dispensing device in the environment of use during its delivery period.
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Abstract
A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the space, (3) a composition comprising a beneficial agent and a non-toxic heat responsive carrier in the space, and (4) a passageway in the housing for delivering the beneficial agent from the dispensing device.
51 Citations
29 Claims
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1. A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising:
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(a) wall means for surrounding and forming an internal space; (b) means in the wall connecting the internal space with the exterior of the dispensing device for releasing beneficial agent from the device; (c) carrier means in the internal space for containing a beneficial agent and for forming a dispensable beneficial agent formulation in the dispensing device when the dispensing device is in the environment of use; (d) a beneficial agent present in the carrier means; (e) expandable means in the internal space for moving from a rested position to an expanded position for occupying an increasing area of the internal space thereby urging the beneficial agent formulation through the means for releasing beneficial agent over time; and
,(f) weight means contained in the expandable means, said weight means possessing a density of at least 1.0 for increasing the density of the dispensing device, thereby maintaining the dispensing device in the environment of use during its delivery period. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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- 14. A delivery system for delivering a beneficial agent formulation to an environment of use, the delivery system comprising:
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15. (a) an inner body member having an internal lumen and provided with an opening for establishing communication with the lumen;
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16. (b) an outer wall surrounding the inner body member, the outer wall comprising in at least a part of a semipermeable composition that is permeable to the passage of fluid;
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17. (c) releasing means in the outer wall for communicating with the lumen and for releasing beneficial agent from the delivery system;
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18. (d) a heat sensitive beneficial agent formulation in the lumen that forms a deliverable formulation at an environment of use temperature of at least 31°
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19. (e) a beneficial agent present in the heat sensitive beneficial agent formulation;
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20. (f) first means in the lumen for expanding and increasing in size, said first means adjacent to the heat sensitive formulation for pushing it through the passageway over time;
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21. (g) second means in the lumen for maintaining the delivery system in the environment of use over time, said second means having a density of at least 1.2 and dispersed throughout said first means.
Specification