Dermal substance collection device
First Claim
1. A dermal substance collection device for the immediate and continuous collection of a dermal substance from a dermal surface, comprising(a) a binding reservoir material for binding with said dermal substance to prevent back transfer loss of said dermal substance from said collection device to the dermal surface;
- (b) a liquid bridge transfer medium which allows the instantaneous and continuous transfer of said dermal substance from the dermal surface to said binding reservoir material, said binding reservoir material being maintained in a wet-state by said liquid bridge transfer medium; and
(c) a cover means for occlusively containing said binding reservoir material and said liquid bridge transfer medium and for occlusively maintaining said liquid bridge transfer medium in continuous contact with the dermal surface upon application of said collection device to the dermal surface.
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0 Petitions
Accused Products
Abstract
A dermal substance collection device (DSCD) is described which provides means for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover.
135 Citations
21 Claims
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1. A dermal substance collection device for the immediate and continuous collection of a dermal substance from a dermal surface, comprising
(a) a binding reservoir material for binding with said dermal substance to prevent back transfer loss of said dermal substance from said collection device to the dermal surface; -
(b) a liquid bridge transfer medium which allows the instantaneous and continuous transfer of said dermal substance from the dermal surface to said binding reservoir material, said binding reservoir material being maintained in a wet-state by said liquid bridge transfer medium; and (c) a cover means for occlusively containing said binding reservoir material and said liquid bridge transfer medium and for occlusively maintaining said liquid bridge transfer medium in continuous contact with the dermal surface upon application of said collection device to the dermal surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A flexible dermal substance collection device for the immediate and continuous collection of a dermal substance from a dermal surface, comprising means for occlusively containing in a cavity a composition, said means containing a composition consisting essentially of
(a) a binding reservoir material for binding with said dermal substance to prevent back transfer loss of said dermal substance from said collection device to the dermal surface; - and
(b) a liquid bridge transfer medium for instantaneous and continuous liquid bridge transfer of said dermal substance from the dermal surface to said binding reservoir material, said binding reservoir material being maintained in a wet-state by said liquid bridge transfer medium, and said occlusive containment means occlusively maintaining a portion of said composition in stationary and continuous contact with the dermal surface upon adhesive application of said collection device thereto.
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Specification