Automatic cardiac capture threshold determination system and method

• US 4,708,142 A
• Filed: 05/28/1985
• Issued: 11/24/1987
• Est. Priority Date: 05/28/1985
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: DeCote, Robert Jr.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US06/738,609
• Time in Patent Office: 910 Days
• Field of Search: 128/419 PG, 128/419 PT
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

An automatic capture threshold determination system and method apply pacing pulses to a patient'"'"'s heart while simultaneously monitoring intracardiac electrical activity to detect evoked cardiac contractions. The system and method automatically adjust the energy of the applied pacing pulses in accordance with a prearranged routine, until capture is obtained, thereby determining the minimum pulse amplitude required to reliably stimulate the heart.

Claims

1. A capture threshold determination system for automatically determining the capture threshold energy level of applied pacing pulses required to reliably stimulate cardiac events in a patient heart, comprising:

pulse generating means responsive to an applied energy level control signal for developing pacing pulses over a predetermined range of energy levels for application to the heart during successive reoccurring intervals;

capture detection means for connection to the heart for detecting cardiac events stimulated during each successive itnerval in response to the pacing pulses generated during that interval, and providing a capture detection signal indicative thereof;

first register means for storing a lower limit pulse energy level and providing an output indicative thereof;

second register means for storing an upper limit pulse energy level and providing an output indicative thereof;

computing means coupled to and responsive to the outputs of said first and second register means for computing the average of said pulse energy levels stored in said first and second register means and providing an output indicative thereof;

pulse amplitude control means coupled to and responsive during an initial one of said intervals to the output of one of said register means, and during subsequent intervals coupled to and responsive to the output of said computing means for producing an energy level control signal for application to said pulse generating means to cause said generating means to produce pacing pulses at the energy level of said one register during said initial interval, and at the average energy levels computed by said computing means during subsequent intervals;

transfer means responsive to said capture detection signal upon completion of each interval for transferring the then existing average pulse energy level indicated by the output of said computing means to said first register means in the event of non-capture during that interval, and to said second register means in the event of capture during that interval, whereby the energy level of said pacing pulses as determined by said energy level control signal approaches the capture threshold level with successive intervals; and

output circuit means coupled to and responsive to the outputs of said register means for providing an output control signal upon the difference between said outputs falling below a predetermined threshold level to indicate generation of pacing pulses at the capture threshold level.

2. A capture threshold determination system as defined in claim 1 wherein said output control signal is applied to said transfer means to inhibit said transfer means from responding to said capture detection signal and thereby prevent the occurrence of further intervals.

3. A capture threshold determination system as defined in claim 1 wherein siad output circuit means further provide an output data signal indicative of the energy level of said pacing pulses generated by said pulse generating means upon said outputs of said register means falling below said predetermined threshold level.

4. A capture threshold determination system as defined in claim 3 wherein said output circuit means are coupled to and provide an output data signal indicative of the output of said second register means.

5. A capture threshold determination system for automatically determining the capture threshold energy level of applied pacing pulses required to reliably stimulate cardiac events in a patient heart, comprising:

pulse generating means responsive to an applied energy level control signal for developing pacing pulses over a predetermined range of energy levels for application to the heart during successive reoccurring intervals;

capture detection means for connection to the heart for detecting cardiac events stimulated during each successive interval in response to the pacing pulses generated during that interval, and providing a capture detection signal indicative thereof;

pulse amplitude control means for producing an energy level control signal for application to said pulse generating means, said generating means being operable to generate during an initial interval pacing pulses at either an upper limit greater than the threshold level, or at a lower limit less than the threshold level and being further operable during subsequent;

intervals to generate pacing pulses at an energy level corresponding to either the average between a new upper limit corresponding to the average between the upper and lower limits of the previous interval and the lower limit of the previous interval upon detection of a cardiac event, or to the average between a new lower limit corresponding to the average between the upper and lower limits of the previous intervals and the upper limit of the previous interval upon non-detection of a cardiac event, whereby the energy level of said pacing pulses with subsequent intervals approaches said threshold level; and

output circuit means coupled to said pulse amplitude control means and responsive to said upper and lower limits for providing an output control signal indicative of generation of pacing pulses at the threshold level upon the difference between said limits falling below a predetermined threshold level.

6. A capture threshold determination systen as defined in claim 5 wherein said output control signal is applied to said pulse amplitude control means to inhibit further change in said energy level control signal.

7. A capture threshold determination system as defined in claim 5 wherein said output circuit means further provide an output data signal indicative of the energy level of said pacing pulses generated by said pulse generating means upon said outputs of said register meaos falling below said predetermined threshold level.

8. The method of automatically determining the threshold energy level of applied pacing pulses required to reliably stimulate cardiac events in a patient heart, comprising:

developing in response to an applied energy level control signal pacing pulses at predetermined energy levels for application to the heart during successive reoccurring intervals;

applying the pacing pulses to the patient heart;

detecting cardiac events stimulated during each successive interval in response to the pacing pulses generated during that interval, and providing a capture detection signal indicative thereof;

storing a lower limit pulse energy level in first register means;

storing an upper limit pulse energy level in second register means;

computing an average pulse energy level from the average of said pulse energy levels stored in said first and second register means;

producing an energy level control signal during an initial one of the intervals corresponding to one of said register means to cause said pacing pulses to be produced at the pulse energy level stored therein;

transferring during each subsequent interval the computed average energy level of the previous interval said first register means in the event of non-capture during that interval, and to said second register means in the event of non-capture during that interval, recomputing the average pulse energy level from the pulse energy levels then stored in said first and second register means, and producing an energy level control signal corresponding to said computed average pulse energy level, whereby during subsequent intervals the energy levels of said pacing pulses approaches the capture threshold level; and

providing in response to the difference between the energy levels in said registers falling below a predetermined threshold level an output control signal indicative of detection of the capture threshold level.

9. The method of capture threshold determination defined in claim 8 including the additional step of providing an output data signal indicative of the energy level of said pacing pulse as the capture threshold level.

10. The method of automatically determining the threshold energy level of applied pacing pulses required to reliably stimulate cardiac events in a patient heart, comprising:

developing in response to an applied energy level control signal pacing pulses at predetermined energy levels for application to the heart during successive reocurring intervals;

applying the pacing pulses to the patient heart;

detecting cardiac events stimulated during each successive interval in response to the pacing pulses generated during that interval, and providing a capture detection signal indicative thereof;

producing an energy level control signal to cause the generation during an initial interval of paciog pulses at either an upper limit greater than the threshold level, or at a lower limit less than the threshold level;

producing an energy level control signal during subsequent intervals to cause the generation of pacing pulses at an average energy level corresponding to either the average between a new upper limit corresponding to the average between the upper and lower limits of the previous interval and the lower limit of the previous interval upon detection of a cardiac event, or to the average between a new lower limit corresponding to the average between the upper and lower limits of the previous interval and the upper limit of the previous interval upon non-detection of a cardiac event, whereby the energy level of said pacing pulses approaches said threshold level with successive intervals;

determining the difference between said upper and lower limits; and

providing in response to said difference falling below a predetermined threshold level an output control signal indicative of detection of the threshold level.

11. The method of capture threshold determination defined in claim 10 including the additional step of providing an output data signal indicative of the energy level of said pacing pulse as the capture threshold level.