Optical fiber catheter with fiber-contained reactive element

• US 4,710,623 A
• Filed: 02/27/1986
• Issued: 12/01/1987
• Est. Priority Date: 02/27/1986
• Status: Expired due to Fees

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Lipson, David, Loebel, Nicolas G., Liu, Benjamin L.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Seo, Chung K.
• Application Number:
  US06/833,245
• Time in Patent Office: 642 Days
• Field of Search: 250/227, 250/231 R, 350/96.1, 128/634
• US Class Current: 250/227.28
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: G01N 2021/7706 Reagent provision
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B

Abstract

An elongated optical fiber apparatus for transmitting a light signal toward a first end of the apparatus situated within a fluid to be analyzed, and for transmitting a returning light signal that is indicative of a specified characteristic of the fluid toward a second end of the apparatus that is situated outside the fluid. The optical fiber apparatus includes a light conductive cable capable of transmitting light with a hole formed in its first end. Disposed substantially entirely within this hole is a reactive element that reacts with the fluid to alter a property of the light that is indicative of a specified characteristic of the fluid.

Claims

1. An elongated optical fiber apparatus for transmitting an incident light signal toward a first end of the apparatus, the first end situated in a fluid, and for transmitting a returning light signal toward a second end of the apparatus that is indicative of a specified characteristic of the fluid, the second end being situated outside the fluid, the apparatus comprising:

a light-conductive cable containing only a single optical fiber capable of transmitting light;

a hole formed in the first end of the single fiber;

a reactive element inserted into said hole to react with the contents of the fluid to alter a property of the light that is indicative of a specified characteristic of the fluid.

2. The apparatus of claim 1 further comprising a coating of a reflective material applied to the first end of the cable.

3. The apparatus of claim 2, wherein the reflective coating is wavelength specific to permit certain wavelengths of the light signal to be reflected by the reflective coating and other wavelengths to pass through the reflective coating.

4. The apparatus of claim 1 wherein substantially the entire surface of said cable is coated with a protective sheath.

5. The apparatus of claim 1 wherein the cable has a central, longitudinal axis and the hole extends axially inwardly into said single fiber from said first end and is centered about the central axis of the cable.

6. The apparatus of claim 1 wherein the cable has a central, longitudinal axis and the hole has a central, longitudinal axis and the hole extends radially inwardly from the outer surface of said cable near said first end such that the central axis of the hole is substantially perpendicular to the central axis of the cable.

7. The apparatus of claim 1 wherein said hole is an annular channel extending circumferentially around the outer surface of said cable near the first end.

8. The apparatus of claim 1 wherein said first end of the cable is planar, and said cable has a central, longitudinal axis, and wherein an angle defined by said first end of the able and said central axis of the cable is orthogonal.

9. The apparatus of claim 1 wherein said first end of the cable is planar, and said cable has a central, longitudinal axis, and wherein an angle defined by said first end of the cable and said central axis of the cable is non-orthogonal.

10. The apparatus of claim 9 wherein said angle defined by said first end of the cable and said central axis of the able is the polarizing angle.

11. The apparatus of claim 1, wherein said first end of the cable is frustoconically shaped.

12. The apparatus of claim 1 wherein said first end of the cable is parabolically shaped.

13. A method of making an optical fiber apparatus for insertion into a fluid for transmitting an incident light signal toward a first end of the apparatus, the first end to be situated inside the fluid, and for transmitting a returning light signal toward a second end of the apparatus that is indicative of a specified characteristic of the fluid, the second end to be situated outside the fluid, comprising the steps of:

providing a light-conductive cable containing only a single otpical fiber having a first end;

forming a hole in said first end of the optical fiber;

filling said hole with a reactive agent to react with the fluid to alter a property of the returning light that is indicative of a specified characterized of the fluid; and

forming a protective sheath around substantially the entire surface of the cable.

14. The method of claim 13 wherein the light-conductive cable has an outer jacket and further including the step of stripping a portion of said outer jacket from the cable near the first end.

15. The method of claim 14 further including the step of applying a reflective coating to said stripped portion of the cable.

16. The method of claim 13 further including the step of applying a reflective coating to said first end of the cable and a portion of the surface of the cable near the first end.

17. Method of claim 13 wherein the hole forming step is performed by laser machining.

18. The method of claim 13 wherein the hole forming step is performed by microdrilling.

19. The method of claim 13 further comprising the step of covering the hole with a semi-permeable membrane whose porosity is chosen to confine the reactive agent within the hole while permitting transport of an analyte.

20. The method of claim 13 further comprising the step of dispersing the reactive agent in a polymeric matrix prior to said filling step.