1.alpha.,25-dihydroxy-26,27-dimethylcholecalciferol and its use in the treatment of calcium pathobolism

• US 4,711,881 A
• Filed: 08/07/1985
• Issued: 12/08/1987
• Est. Priority Date: 08/10/1984
• Status: Expired due to Fees

• Current Assignee: Taisho Pharmaceutical Company Limited (Taisho Pharmaceutical Holdings Company Limited)
• Original Assignee: Taisho Pharmaceutical Company Limited (Taisho Pharmaceutical Holdings Company Limited)
• Inventors: Ikekawa, Nobuo
• Primary Examiner(s): Schenkman, Leonard
• Assistant Examiner(s): Lipovsky, Joseph A.
• Application Number:
  US06/763,568
• Time in Patent Office: 853 Days
• Field of Search: 260/397.2, 514/167
• US Class Current: 514/167
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 3/14 for calcium homeostasis vitamin D A61P3/02; parathyroid hormones A61P5/18; calcitonin A61P5/22; osteoporosis A61P19/10; bone metastasis A61P35/04
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/12 for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
• CPC Class Codes: C07C 401/00 Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
• CPC Class Codes: C07J 9/00 Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
• CPC Class Codes: C07J 9/005 containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Abstract

1α,25-Dihydroxy-26,27-dimethylcholecalciferol represented by formula: ##STR1## This compound is prepared by irradiating 26,27-dimethylcholesta-5,7-diene-1α,3β,25-triol with ultraviolet light, and is useful for the prevention or treatment of calcium pathobolism or osteoporosis.

Claims

1. 1α

,25-Dihydroxy-26,27-dimethylcholecalciferol represented by formula;

##STR3##

2. A pharmaceutical composition for the prevention or treatment of calcium pathobolism or osteoporosis, which comprises an amount, effective for the prevention or treatment of said diseases, of 1α

,25-dihydroxy-26,27-dimethylcholecalciferol, and a pharmaceutically acceptable diluent or carrier.

3. A method for the prevention or treatment of calcium pathobolism or osteoporosis, which comprises administering to a mammal an effective amount of 1α

,25-dihydroxy-26,27-dimethylcholecalciferol.