Applicator for non-invasive transcutaneous delivery of medicament

• US 4,713,050 A
• Filed: 10/24/1986
• Issued: 12/15/1987
• Est. Priority Date: 10/12/1984
• Status: Expired due to Term

• Current Assignee: Drug Delivery Systems Incorporated
• Original Assignee: Drug Delivery Systems Incorporated
• Inventors: Sibalis, Dan
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US06/922,518
• Time in Patent Office: 417 Days
• Field of Search: 604/20, 128/798, 128/802, 128/803, 128/82.1
• US Class Current: 604/20
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An indicator for the electrophoretic deposition of a medicament through or on a skin surface. The device includes layers forming a reservoir containing the drug, a battery layer superimposed on the reservoir, and a cover of electrically conductive material fully enclosing the layers and having a lip along its periphery to electro-conductively engage the skin surface and form an electrical circuit.

Claims

1. A self-contained electrically powered drug applicator for the migration of medicament through the skin into the blood stream of a patient comprising:

reservoir means containing said medicament forming a first electrode, battery means for charging/driving the medicament, means for covering comprising an electrically conductive material for partially enclosing at least said reservoir means leaving a side of said reservoir means exposed for contacting the skin, said cover means, being electrically connected to said battery means, and having a lip defining the periphery of said applicator and forming a second electrode for making contact with said skin when mounted on said skin leaving at least said reservoir means fully enclosed, and an electrically conductive adhesive material coating disposed on at least the underside of said lip, whereby when said applicator is adhered to said skin a complete electrical circuit between said first and second electrodes and through said skin is formed so as to drive said medicament out of said reservoir means and through said skin into the blood stream of said patient.

2. The applicator according to claim 1, in which said reservoir means is made from a microporous material whereby said medicament provides an electrical path therethrough.

3. The applicator according to claim 1, wherein said cover means and said reservoir means being thin in construction and conformable to the body.

4. The applicator according to claim 1, wherein said circuit having means to maintain constant current flow during the period said medicament is delivered.

5. The applicator according to claim 1, wherein said circuit having means to terminate deposition of said medicament after a predetermined quantity of medicament is delivered.

6. The applicator according to claim 5, said circuit including a reverse plating cell.