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Process for preparing antithrombogenic/antibiotic polymeric plastic materials

  • US 4,713,402 A
  • Filed: 08/30/1985
  • Issued: 12/15/1987
  • Est. Priority Date: 08/30/1985
  • Status: Expired due to Fees
First Claim
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1. A process for producing plastic substrates having antithrombogenic and/or antibiotic properties without dissolving the substrate, characterized by(a) providing a dual organic solvent system, said dual organic solvent system comprising(1) a chlorofluorocarbon component, said chlorofluorocarbon component being a member selected from the group consisting of 1,1,2-trichloro-1,2,2-trifluoroethane;

  • 1,2-difluoro-1,1,2,2-tetrachloroethane;

    1,1-difluoro 1,2,2,2-tetrachloroethane, and mixtures thereof;

    (2) a petroleum ether component; and

    (3) the ratio of said chlorofluorocarbon component to said petroleum ether component being within the range of between about nine parts chlorofluorocarbon to one part petroleum ether and one part chlorofluorocarbon to one part petroleum ether;

    (b) dissolving in said dual organic solvent system from said providing step a pre-formed quaternary ammonium antibiotic and/or antithrombogenic complex;

    (c) immersing a plastic material in said dual organic solvent system containing said quaternary ammonium antibiotic and/or antithrombogenic complex from said dissolving step, said plastic material being non-dissolvable in said organic solvent system;

    (d) removing in a first removing step said plastic material from said immersing step; and

    (e) removing in a second removing step said solvent from said dissolving step;

    (f) thereby providing a passively coated thin layer film of quaternary ammonium antibiotic and/or anticoagulant complex on said plastic surface.

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