Methods for NMR angiography

• US 4,714,081 A
• Filed: 03/03/1986
• Issued: 12/22/1987
• Est. Priority Date: 03/03/1986
• Status: Expired due to Term

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Dumoulin, Charles L., Hart, Howard R. Jr.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Smith, Ruth S.
• Application Number:
  US06/835,683
• Time in Patent Office: 659 Days
• Field of Search: 128/653, 324/306, 324/309, 324/312, 324/307
• US Class Current: 600/419
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography

Abstract

Magnetic field gradient and radio-frequency (RF) pulse signal sequences permitting moving nuclear spins to be selectively detected and then displayed as projected angiographic data in a nuclear magnetic resonance (NMR) image, without the use of contrast agents. The method allows the intensity of an image pixel to be determined by the macroscopic detected spin velocity and can provide essentially complete suppression of non-moving spins. Resulting images have high signal-intensity dynamic range for detected vessels. The selected detection of moving flows is not dependent upon pulsatile flow so that venous and arterial structures are equally as well visualized in high-resolution NMR angiographic images.

Claims

1. A method for providing a nuclear magnetic resonance (NMR) angiographic projection image of flowing fluids in at least a selected portion of a sample, comprising the steps of:

(a) immersing the sample in a main static magnetic field;

(b) nutating, in the initial portion of each of a first sequence and a second sequence of a sequential pair of imaging sequences, the spins of all nuclei of a selected species;

(c) providing an evolution time interval after step (b) in each of the pair of sequences;

(d) applying, in the evolution time interval of at least one of the first and second sequences of each sequence pair, a pair of flow-encoding gradient field pulses in a first magnetic field gradient impressed upon the sample, in a first direction selected to establish one axis of the NMR angiographic projection image, to cause a resulting NMR response signal from the spin of moving nucleus to differ from the NMR response signal resulting from the spin of a substantially stationary nucleus;

(e) then applying a magnetic field gradient pulse in a second direction, orthogonal to the first direction, to dephase, and enhance suppression of, response signals from spins from all stationary nuclei of the selected species;

(f) then acquiring, responsive to at least a second magnetic field gradient impressed upon the sample in the second direction, a set of data from the NMR response signals evoked from at least the sample portion in each of a response data acquisition portion of the first and second sequences;

(g) substracting the data of one of the NMR response signal data sets acquired in the first and second sequences from the data of the other data set to substantially remove response data obtained from the substantially stationary nuclei; and

(h) generating, responsive to the remaining response data, the NMR angiographic projection image as a two-dimensional projection, lying in a plane in the first and second directions, of the fluid flow in the three-dimensional sample.

2. The method of claim 1, wherein step (d) includes the steps of:

applying a flow-encoding pair of first magnetic field gradient pulses in each of the first and second sequences;

causing each pulse of the pair to have a polarity different from the polarity of the other pulse; and

causing the polarity of the first pulse of each pair to alternate in each different one of the pair of sequences.

3. The method of claim 2, wherein step (d) further includes the step of providing the four flow-encoding gradient pulse signals of each sequence pair with a substantially constant amplitude.

4. The method of claim 3, further comprising the steps of:

repeating the sequence of steps (b)-(f) in a predetermined plurality of total repetitions;

providing in each repetition a different value of a phase-encoding signal in the magnetic field gradient in the first direction; and

generating the image of step (g) from the totality of difference data sets obtained from all of the sequence pairs.

5. The method of claim 4, further comprising the steps of:

processing the remaining response data of step (g) to obtain a first set of intensity I₁ date for each pixel in the chosen angiographic projection plane;

repeating the total plurality of repetitions of the sequence of steps (b)-(g) with the first magnetic field gradient repositioned, in each repetition, along at least one other one of a second and third axis in a Cartesian coordinate system;

processing the remaining response data of the step (g) of each repetition of the sequence of steps (b)-(g), to obtain a different designated set of intensity I₂ and I₃ data, respectively, for each pixel in the angiographic projection plane chosen for the repetition along the respective second and third axis; and

processing, for each image pixel, the intensity data obtained for that image pixel for each of the different first gradient portions, to provide the RMS average intensity I_total =(I₁² +I₂² +I₃²)^1/2, of the totality of difference data sets for image generation.

6. The method of claim 3, further comprising the step of adjusting the time duration T_g of each gradient pulse to accept for imaging, without aliasing, the range of fluid flow velocities in the sample.

7. The method of claim 2, wherein step (b) comprises the step of applying a radio-frequency (RF) magnetic field to the sample with sufficient energy to nutate the net magnetization of the nuclear spins through an angle substantially equal to 90 degrees.

8. The method of claim 7, wherein the nutation of spins is to occur substantially only in the selected sample portion, and further comprising the step of applying the magnetic field gradient, in the first direction, to the sample during application of the RF magnetic field.

9. The method of claim 8, wherein the RF magnetic field is applied as a pulsed signal having a sin(x)/x envelope shape.

10. The method of claim 7, wherein step (c) further comprises the step of refocusing the spins of the nutated nuclei prior to applying the flow-encoding gradient magnetic field pulses.

11. The method of claim 10, wherein the refocusing step includes the steps of:

applying the magnetic field gradient in the first direction, and applying the RF magnetic field to the sample with sufficient energy to nutate the net magnetization of the nuclear spins through an angle substantially equal to 180 degrees.

12. The method of claim 1, wherein step (d) includes the steps of:

applying a flow-encoding pair of first magnetic field gradient pulses in only the first sequence; and

causing each pulse of the pair to have the same polarity.

13. The method of claim 12, wherein step (d) further includes the step of providing each of the pair of flow-encoding gradient pulse signals of each first sequence with a substantially constant amplitude.

14. The method of claim 13, further comprising the steps of:

repeating the sequence of step (b)-(f) in a predetermined plurality of total repetitions;

providing in each repetition a different value of a phase-encoding signal in the magnetic field gradient in the first direction; and

generating the image of step (g) from the totality of difference data sets obtained from all of the sequence pairs.

15. The method of claim 14, further comprising the steps of:

processing the remaining response data of step (g) to obtain a first set of intensity I₁ data for each pixel in the chosen angiographic projection plane;

repeating the total plurality of repetitions of the sequence of steps (b)-(g) with the first magnetic field gradient repositioned, in each repetition, along at least one other one of a second and third axis in a Cartesian coordinate system;

processing the remaining response data of the step (g) of each repetition of the sequence of steps (b)-(g), to obtain a different designated set of intensity I₂ and I₃ data, respectively, for each pixel in the angiographic projection plane chosen for the repetition along the respective second and third axis; and

processing, for each image pixel, the intensity data obtained for that image pixel for each of the different first gradient portions, to provide the RMS average intensity I_total =(I₁² +I₂² +I₃²)^1/2, of the totality of difference data sets for image generation.

16. The method of claim 13, further comprising the step of adjusting the time duration T_g of each gradient pulse to accept for imaging, without aliasing, the range of fluid flow velocities in the sample.

17. The method of claim 12, wherein step (b) comprises the step of applying a radio-frequency (RF) magnetic field to the sample with sufficient energy to nutate the net magnetization of the nuclear spins through an angle substantially equal to 90 degrees.

18. The method of claim 17, wherein the nutation of spins is to occur substantially only in the selected sample portion, and further comprising the step of applying the magnetic field gradient, in the first direction, to the sample during application of the RF magnetic field.

19. The method of claim 18, wherein the RF magnetic field is applied as a pulsed signal having a sin(x)/x envelope shape.

20. The method of claim 17, wherein step (d) further comprises the step of refocusing the spins of the nutated nuclei in between the application of the first and second flow-encoding gradient magnetic field pulses.

21. The method of claim 20, wherein the refocusing step includes the steps of:

applying the magnetic field field to the sample with sufficient energy to nutate the net magnetization of the nuclear spins through an angle substantially equal to 180 degrees.

22. The method of claim 1, wherein the sample is a portion of human anatomy, and further comprising the step of gating the commencement of each sequence with respect to a designated point in the cardiac cycle of the human sample.