Drug dispenser comprising a multiplicity of members acting together for successfully dispensing drug

• US 4,716,031 A
• Filed: 02/12/1986
• Issued: 12/29/1987
• Est. Priority Date: 03/21/1984
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B., Theeuwes, Felix, Deters, Joseph C.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/828,810
• Time in Patent Office: 685 Days
• Field of Search: 604/890, 424/15, 424/19, 424/20, 424/21, 424/22, 424/37, 424/38
• US Class Current: 424/453
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.

Claims

1. A dispenser for delivering a beneficial drug at a controlled rate to a fluid biological environment of use having a temperature greater than 32°

C., the dispenser comprising;

(a) a wall comprising a semipermeable polymeric composition that is permeable to the passage of a fluid present in the environment of use and substantially impermeable to the passage of a beneficial drug, the semipermeable wall surrounding in at least a part;

(i) an internal container, which container is a member selected from the group consisting of a one-piece capsule and a two-piece capsule comprising an internal compartment, said capsule member formed of a non-toxic composition adapted to be admitted into the biological environment of use comprising the gastrointestinal tract;

(ii) first means in the compartment for changing from a storable composition to a dispensable composition in response to the temperature of the biological environment, said first means a member selected from the group consisting of a glycerol ester of a fatty acid, polyethylene glycol, a block polymer of butylene oxide and ethylene oxide, a block polymer of propylene oxide and ethylene oxide, and a block polymer of polyoxyalkylene and propylene glycol;

(iii) a beneficial gastrointestinal administrable drug in the means responsive to temperature;

(iiii) a second means in the compartment for imbiding fluid through the semipermeable wall and for expanding in the compartment, said second means a member selected from the group consisting of a polysaccharide, and acidic carboxy polymer, a polyethylene oxide, and a starch composition, said second means in contacting arrangement with the first means; and

,

(b) at least one passageway through the wall and through the container connecting the exterior of the dispenser with the first means for dispensing the beneficial drug from the dispenser.

2. The dispenser for delivering a beneficial agent at a controlled rate to a biological environment according to claim 1, wherein said first means is a lamina.

3. The dispenser for delivering a beneficial agent at a controlled rate to a biological environment according to claim 1, wherein said second means is a lamina.