Laminar arrangement for increasing delivery of beneficial agent from dispenser

• US 4,717,568 A
• Filed: 08/11/1986
• Issued: 01/05/1988
• Est. Priority Date: 08/09/1985
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Landrau, Felix A., Eckenhoff, James B., Cortese, Richard
• Primary Examiner(s): Griffin, Ronald W.
• Application Number:
  US06/895,610
• Time in Patent Office: 512 Days
• Field of Search: 428/320.2, 424/15, 424/468, 424/469
• US Class Current: 424/469
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: Y10T 428/249994 Composite having a component wherein a constituent is liquid or is contained within preformed walls [e.g., impregnant-filled, previously void containing component, etc.]

Abstract

A laminated arrangement useful for manufacturing a deliver device for delivering a beneficial agent formulation is disclosed. The laminated arrangement comprise first lamina means comprising a beneficial agent formulation in laminar arrangement with a second lamina means exhibiting a lower passage to the beneficial agent then the first lamina means.

Claims

1. A laminated arrangement useful for manufacturing a delivery device for delivering a beneficial agent formulation to an animal, wherein the laminated arrangement comprises:

first lamina means for absorbing heat from the animal for forming a dispensable formulation, said first lamina means comprising a beneficial agent formulation that produces a beneficial effect when dispensed to an animal, which first lamina means is in laminar arrangement with a second lamina means, said second lamina having means for lessening unwanted migration of beneficial agent from the first lamina means, said second lamina means exhibiting a lower passage to the beneficial agent then the first lamina means there by lessening migration from the first lamina means into the second lamina means, and wherein when the laminated arrangement is in a delivery device in operation, which delivery device comprises means for producing an expandable force for assisting in operating the delivery device, the first lamina and the second lamina operate as a cooperating means for increasing the delivery of the beneficial agent from the delivery device.

2. A laminated arrangement useful for manufacturing a delivery device for delivering a beneficial agent formulation to a animal, wherein the laminated arrangement comprises:

a first lamina means for absorbing fluid from the animal for increasing the size of the first lamina means 2 to 50 fold, thereby producing an expanding force that is applied against a beneficial agent formulation present in the delivery device for dispensing the formulation from the delivery device, and a second lamina means in laminar arrangement with the first lamina means, said second lamina means for directing the expanding force received from the first lamina means against a beneficial agent formulation present in the delivery device for aiding in the delivery of a beneficial agent formulation from the dispensing device, and which second lamina exhibits a decrease passage to the beneficial agent and acts with the first lamina for increasing the delivery of the beneficial agent from the dispenser.