Method for determining diastolic arterial blood pressure in a subject

• US 4,718,426 A
• Filed: 01/22/1987
• Issued: 01/12/1988
• Est. Priority Date: 02/17/1984
• Status: Expired due to Fees

• Current Assignee: Cortronic Corporation
• Original Assignee: Cortronic Corporation
• Inventors: Russell, Ted W.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/006,626
• Time in Patent Office: 355 Days
• Field of Search: 128/672, 128/677-686
• US Class Current: 600/492
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02156 Calibration means
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/0235 Valves specially adapted therefor

Abstract

Apparatus and related methods for continuous long-term non-invasive measurement of the pressure of a pulsatile fluid flowing through a flexible tube, particularly human arterial blood flow, is disclosed. Specifically, the apparatus provides a continuous calibrated pressure measurement by first undertaking a "calibration" phase comprised of determining the pressure at various pre-defined conditions of flow and, in response thereto, ascertaining the values of a plurality of coefficients each of which is associated with a corresponding term in a pre-defined function that characterizes fluid pressure in relation to pulsatile displacement of the wall of the tube; and second, undertaking a "continuous monitoring" phase comprised of determining each subsequently occurring pressure value as the pre-defined function of each corresponding pulsatile wall displacement value, and re-initiating the calibration phase at the expiration of pre-defined time intervals which adaptively change based upon current and prior results. Methods, which are particularly useful in conjunction with the disclosed apparatus, for ascertaining systolic and diastolic arterial blood pressure values are also disclosed.

Claims

1. A method of determining a measure of the diastolic arterial blood pressure in a subject comprising the steps of:

determining a group, of a pre-selected number of sequentially occurring individual pressure waveforms, from all the pressure waveforms occurring during deflation of an occlusive cuff, wherein said group possesses maximum average amplitude,

selecting, in accordance with pre-selected criteria, at least one individual pressure waveform from the group and setting mean pressure of the subject equal to the occlusive cuff pressure corresponding to the selected individual pressure waveform,

determining the systolic pressure of the subject, and

ascertaining the measure of diastolic pressure in accordance with the formula;

space="preserve" listing-type="equation">D=AM-Sy/(A-Y)

for at least a chosen one of all of said pressure waveforms in which

D is the measure of diastolic pressure, A is the uncalibrated peak amplitude of said chosen pressure waveform, Y is the mean value (area/duration) of said chosen pressure waveform, and S and M are the systolic and mean pressure values respectively, associated with said subject.

2. The invention in claim 1 in which said selecting step is comprised of the steps of determining a second group of a preselected number of sequentially occurring pressure waveforms from all of said waveforms occurring subsequent to said selected individual pressure waveform.

3. The invention in claim 2 in which the selecting step includes the step of ascertaining the mean pressure as being subsequently equal to the occlusive cuff pressure occurring at the time of the peak of said selected individual pressure waveform.

4. The invention in claim 3 in which the measure ascertaining step further includes the step of:

determining, in accordance with said formula, a diastolic pressure estimate for each pressure waveform in said second group and averaging all the estimates to produce said first measure of diastolic pressure.

5. The invention in claim 1 in which said individual pressure waveform selecting step is comprised of the steps of:

determining whether said selected waveform was caused by an artifact by comparing the peak amplitude of said selected individual waveform against a pre-determined limit, and

rejecting the selected individual waveform in the event the limit is exceeded and selecting another waveform until such limit is no longer exceeded.