Implantable hyperthermia device and system

• US 4,719,919 A
• Filed: 02/04/1985
• Issued: 01/19/1988
• Est. Priority Date: 01/21/1983
• Status: Expired due to Fees

• Current Assignee: Cook Incorporated (Cook Group Incorporated)
• Original Assignee: RAMM Associates A Partnership
• Inventors: Moran, Christopher, Rutledge, Raymond E., Alek, Robert B., Marchosky, Jose A.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Hindenberg, Max F.
• Application Number:
  US06/697,697
• Time in Patent Office: 1,079 Days
• Field of Search: 128/303.1, 128/303.12, 128/399, 128/402, 128/736, 128/742, 128/419 PG, 128/784, 128/903, 128/401, 604/20
• US Class Current: 607/113
• CPC Class Codes: A61B 2017/00022 Sensing or detecting at the treatment site
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61F 2007/0093 programmed
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/00 Heating or cooling appliances for medical or therapeutic treatment of the human body heating or cooling means in connection with bedsteads or mattresses A47C21/00 ; massage, therapeutic baths A61H; hyperthermia using electric or magnetic fields or ultrasound A61N; electric heating elements H05B
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 2005/1012 Templates or grids for guiding the introduction of sources
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: H02J 2310/23 The load being a medical device, a medical implant, or a life supporting device
• CPC Class Codes: H02J 50/10 using inductive coupling

Abstract

A system for generating heat and sensing the temperature in an internal body organ such as in a tumor and for gaining information about the tumor for diagnosis and other purposes comprising a first system portion which is preferably entirely implantable beneath the skin of the person being treated or diagnosed including a probe device having electrical heater and sensor elements in it for implanting extending into the tumor to be treated and including an internal control unit also implantable under the skin and operatively connected to the heater and sensor elements in the probe, the internal control unit also including an electronic control unit for controlling the energizing of the heater element and having a sensor responsive portion responsive to the temperature sensed by the sensor element, and a transmitter/receiver device and a second system portion including an external control unit having a transmitter/receiver device for positioning on the skin adjacent to the internal transmitter/receiver device for exchanging information between the internal and the external control units, the external control unit also including a computer and associated computer control devices and software. The external control unit also includes system elements for controlling the application of electric energy to the heater element to generate heat in the body organ. The internal control unit may also include a rechargeable energy source rechargeable under control of the external control unit.

Claims

1. A hyperthermia system for treating a cancerous brain tumor, comprising a system entirely implantable beneath the skin of the person being treated, said implantable system including a probe having opposite ends including a first end for extending into the brain tumor to be treated and a second end extendable therefrom to adjacent the surface of the skin, an electric heater element and a heat sensitive member mounted in the probe adjacent to the first end, and means for thermally insulating said heat sensitive member from said heater element, means operatively connected to the probe to select a predetermined temperature condition to be produced in the tumor, an electronic control unit under control of the means operable to select, and means operatively connecting the electronic control unit to the heater element and to the heat sensitive member, said electronic control unit including an energy source for the implantable system and means under control of the electronic control unit to apply energy from the energy source to the heater element to generate the selected predetermined temperature condition in the brain tumor to be treated adjacent to the probe, and closed-loop control means in the electronic control unit responsive to the condition of the heat sensitive member for controlling the application of energy to the heater element according to the difference between the selected predetermined and actual temperature conditions in the brain tumor being treated, the implant table system also including a programmable circuit including a memory circuit, and transmission and receiving means, said means operable to select, said electronic control unit and said programmable circuit being implantable in a remote location in the person'"'"'s body, and an external control system having transmission and receiving means therein for coupling to the transmission and receiving means of the implantable system through the skin, said external control system including programmable means operable for programming the memory in the implantable system to establish the temperature conditions to be produced in the brain tumor being treated.

2. The hyperthermia system of claim 1 wherein the external control system includes means operable for energizing the heater element to produce and maintain the predetermined treatment temperature in the brain tumor being treated.

3. The hyperthermia system of claim 1 wherein the external control system includes means for selecting a predetermined time for maintaining the heater element energized to maintain the predetermined treatment temperature in the brain tumor being treated.

4. The hyperthermia system of claim 1 wherein the external control system includes means for establishing a predetermined frequency of treatment cycles when the heater element is energized.

5. The hyperthermia system of claim 1 wherein the energy source includes a rechargeable energy source, and means in the external control system operating through the transmission and receiving means when they are coupling the internal and external control systems for recharging the rechargeable energy source.

6. A hyperthermia system for treating a cancerous brain tumor, comprising a system entirely implantable beneath the skin of the person being treated, said implantable system including a probe having opposite ends including a first end for extending into the brain tumor to be treated and a second end extendable therefrom to adjacent the surface of the skin, an electric heater element and a heat sensitive member mounted in the probe adjacent to the first end, means operatively connected to the probe to select a predetermined temperature condition to be produced in the tumor, an electronic control unit under control of the means operable to select, and means operatively connecting the electronic control unit to the heater element and to the heat sensitive member, said electronic control unit including an energy source for the implantable system and means under control of the electronic control unit to apply energy from the energy source to the heater element to generate the selected predetermined temperature condition in the brain tumor to be treated adjacent to the probe, and closed-loop control means in the electronic control unit responsive to the condition of the heat sensitive member for controlling the application of energy to the heater element according to the difference between the selected predetermined and actual temperature conditions in the brain tumor being treated, the implantable system also including a programmable circuit including a memory circuit, and transmission and receiving means, said means operable to select, said electronic control unit and said programmable circuit being implantable in a remote location in the person'"'"'s body, and an external control system having transmission and receiving means therein for coupling to the transmission and receiving means of the implantable system through the skin, said external control system including programmable means operable for programming the memory in the implantable system to establish the temperature conditions to be produced in the brain tumor being treated.

7. The hyperthermia system of claim 6 wherein the external control system includes means operable for energizing the heater element to produce and maintain the predetermined treatment temperature in the body tissue being treated.

8. The hyperthermia system of claim 6 wherein the external control system includes means for selecting a predetermined time for maintaining the heater element energized to maintain the predetermined treatment temperature in the body tissue being treated.

9. The hyperthermia system of claim 6 wherein the external control system includes means for establishing a predetermined frequency of treatment cycles when the heater element is energized.

10. The hyperthermia system of claim 6 wherein the energy source includes a rechargeable energy source, and means in the external control system operating through the transmission and receiving means when they are coupling the internal and external control systems for recharging the rechargeable energy source.