Device for the evaluation of a flat test carrier for the analytical determination of components of body fluids

• US 4,720,372 A
• Filed: 06/11/1984
• Issued: 01/19/1988
• Est. Priority Date: 06/16/1983
• Status: Expired due to Term

• Current Assignee: Roche Diagnostics GmbH (Roche Holding AG)
• Original Assignee: Boehringer Mannheim GmbH (Roche Holding AG)
• Inventors: Fey, Werner, Seidenstricker, Manfred, Ruppender, Uwe, Pauli, Manfred
• Primary Examiner(s): Lacey, David L.
• Assistant Examiner(s): Delahunty, C. M.
• Application Number:
  US06/619,017
• Time in Patent Office: 1,317 Days
• Field of Search: 422/63, 422/64, 422/66, 422/68, 422/67, 436/46, 436/50, 219/543, 219/499, 219/449, 219/464, 219/504
• US Class Current: 422/67
• CPC Class Codes: G01N 2021/478 Application in testing analytical test strips
• CPC Class Codes: G01N 21/0332 with temperature control control of temperature G05D23/00; cryostats F17C3/08
• CPC Class Codes: G01N 21/8483 Investigating reagent band test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04
• CPC Class Codes: G05D 23/2401 using a heating element as a sensing element

Abstract

The present invention provides a device for the evaluation of a flat test carrier for the analytical determination of components of body fluids, said device having a tempering device and a regulating unit, the tempering device including a heating and measurement unit which can be pressed flatly against the test carrier in the region of its reference surface utilized for the evaluation and having a heating surface, wherein the heating and measurement unit has a heating surface which can be homogeneously heated with at least one resistance heating element, at least one resistance heating element is associated at least partly in close proximity to the heating surface, at least one part, serving as temperature measurement section, of the part of the resistance heating element arranged in the neighborhood of the heating surface consisting of a material with a temperature-dependent electrical resistance and the electrical resistance of the temperature measurement section is used for the regulation of the temperature of the heating and measurement unit by means of the regulating unit so that a part of the heating element simultaneously serves as temperature measurement element.

Claims

1. The combination of a test carrier having a test field and a device for the evaluation of said test carrier for the analytical determination of components of body fluids, comprising:

a test carrier having a test field; and

a device for the evaluation of said test carrier for the analytical determination of components of body bluids comprising;

a tempering device and a regulating unit, the tempering device including at least one heating and measurement unit, said at least one heating and measurement unit having a heating surface which can be homogeneously heated with at least one resistance heating element and which can be pressed flatly against the test carrier in the region of the test fieldutilized for the evaluation;

at least one resistance heating element having at least one first part arranged in close proximity to the heating surface;

said at least one first part having at least one portion thereof which serves as temperature measurement section, arranged in close proximity to the heating surface and comprising a material with a temperature-dependent electrical resistance to form at least one combined heating and temperature measuring element; and

said at least one heating and measurement unit including a flat substrate and said at least one resistance heating element including resistance strips carried on a first surface of the substrate, the substrate comprising said heating surface, said heating surface being at least substantially as large as the test field of the test carrier used for the evaluation, the resistance strips being so dimensioned and distributed that there is obtained a uniform distribution of the electrical power density on said first substrate surface, at least a part of the resistance strips forming said at least one combined heating and temperature measuring element;

said at least one combined heating and temperature measuring element being associated with said regulating unit so that the electrical resistance of the temperature measurement section is used for the regulation of the temperature of the heating and measurement unit by means of the regulating unit.

2. The combination according to claim 1, in which the regulating unit includes two reference resistors in a measurement bridge having a bridge diagonal and wherein in said tempering device said at least one first part of said at least one resistance heating element arranged in close proximity to the heating surface includes at least two portions which serve as temperature measurement sections which are connected to form combined heating and temperature measuring elements with the two reference resistors in the measurement bridge in such a manner that the voltage of the bridge diagonal corresponds to the actual temperature value of the heating surface.

3. The combination according to claim 1, wherein the regulating unit includes circuit means for applying increased heating power for short period of time, after the heating surface is pressed against the test carrier.

4. The combination according to claim 1, wherein the regulating unit includes a measurement device for measuring the temperature of the surroundings of the heating and measurement unit in order to introduce a correction signal corresponding to this temperature to the regulating unit.

5. The combination according to claim 1, wherein the substrate includes a heat conductive plate forming said heating surface on one side thereof and a ceramic plate of at most 2 mm. thickness positioned adjacent and extending essentially parallel to said heat conductive plate, said ceramic plate having a side lying opposite the heating surface on which said resistance strips are vapour deposited, said resistance strips being of a metal with temperature-dependent resistance.

6. The combination according to claim 5, wherein the heat conductive plate comprises a metal plate and the heating surface is located on one side of said metal plate opposite the side of the metal plate with which the side of the ceramic plate is full-facedly connected.

7. The combination according to claim 1 wherein said test carrier has a first side which carries said test field and a second side opposite said first side, wherein the tempering device includes at least two heating and measurement units, a first one of which can be pressed on from the first side carrying the test field and the second heating and measurement unit can be pressed from the second side against the test carrier, the heating and measurement unit associated with the first side having a through-opening for light and having on each of the opposite-lying sides of this opening one of said at least one combined heating and temperature measuring elements.

8. The combination according to claim 7, wherein the test carrier has lower and upper sides, said first side being said upper side and said second side being said lower side, wherein said tempering device includes a reception slider for said test carrier and wherein the second heating and measurement unit associated with the lower side of the test carrier is disposed on said reception slider for the test carrier, which reception slider is movable from a reception position into a measurement position, and wherein said second heating and measurement unit associated with the lower side of the test carrier is positioned and arranged on said reception slider so that when the test carrier is disposed ons aid reception slider said test carrier may be heated even during the movement of the reception slider into the measurement position for the pupose of preheating the test carrier so that there is present only a predetermined small temperature difference from a desired temperature value and, wherein said first heating and measurement unit is positioned and arranged adjacent the measurement position so that the test field of the test carrier can be pressed against the first heating and measurement unit when the test carrier carried by the reception slider is in the measurement position, the small temperature differences thereby being equalized.