Method of predicting the occurrence of deep vein thrombosis by non-invasive measurement of vessel diameter

• US 4,721,113 A
• Filed: 09/20/1985
• Issued: 01/26/1988
• Est. Priority Date: 09/20/1985
• Status: Expired due to Fees

• Current Assignee: Temple University of The Commonwealth System of Higher Education
• Original Assignee: Temple University of The Commonwealth System of Higher Education
• Inventors: Ziskin, Marvin C., Philips, Charles M., Alburger, Philip D., Lachman, John W., Stewart, Gwendolyn J.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Smith, Ruth S.
• Application Number:
  US06/778,589
• Time in Patent Office: 858 Days
• Field of Search: 128/660, 128/663, 128/133, 128/134, 128/630, 128/668, 128/694, 73/612, 73/861.25
• US Class Current: 600/449
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces
• CPC Class Codes: A61B 8/40 Positioning of patients, e.g. means for holding or immobilising parts of the patient's body
• CPC Class Codes: A61B 8/4218 characterised by articulated arms

Abstract

A method of predicting the occurrence of deep vein thrombosis after a surgical procedure comprises monitoring changes in the internal diameter of a blood vessel using a non-invasive ultrasound technique. The frequency and magnitude of changes in vessel diameter are used to predict whether deep vein thrombosis will occur.

Claims

1. A procedure for predicting the occurrence of deep vein thrombosis by observing intra-vessel diameter changes using non-invasive pulse generating techniques comprising the steps of:

(a) immobilizing a part of a subject having a vein;

(b) positioning a probe over the vein of the part of the subject;

(c) generating an incident ultrasonic pulse and directing the incident pulse toward an anterior wall of the vein;

(d) receiving echoes indicative of the presence of each of anterior and posterior walls of the vein and being caused by an acoustic discontinuity therebetween, each echo being a reflected pulse having a leading and a trailing edge;

(e) providing an indication of the time difference between the occurence of the trailing edge of the echo indicative of the presence of the anterior wall and the leading edge of the echo indicative of the presence of the posterior wall, the difference being an indication of vein diameter and the vein diameter being calculated therefrom;

(f) providing a real time analog recording of vein diameter versus time;

(g) monitoring changes in vein diameter over time while the subject is undergoing a surgical procedure;

(h) predicting, based upon magnitude of dilations in vein diameter, whether deep vein thrombosis will occur.

2. The procedure according to claim 1 wherein immobilizing the part of the subject includes the steps of:

providing an impression casting for immobilizing the part; and

securing the impression casting on a support table.

3. A procedure for predicting the occurence of deep vein thrombosis in a subject:

monitoring changes in a vein'"'"'s diameter over time while the subject is undergoing a surgical procedure; and

predicting, based upon the magnitude of the changes, whether deep vein thrombosis will occur throughout the subject.