Iridium treatment of neuro-stimulating electrodes

• US 4,721,551 A
• Filed: 11/06/1986
• Issued: 01/26/1988
• Est. Priority Date: 11/06/1986
• Status: Expired due to Term

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Zimmerman, Peter, Sutter, Mitchell, Byers, Charles L., Feinstein, Paul
• Primary Examiner(s): Demers, Arthur P.
• Application Number:
  US06/927,809
• Time in Patent Office: 446 Days
• Field of Search: 204/47, 204/280, 204/290 R, 204/291, 204/292, 128/303.13, 128/635
• US Class Current: 623/24
• CPC Class Codes: C25D 7/00 Electroplating characterised by the article coated

Abstract

Microelectrodes of the art are limited to the charge density which can pass through them. The present invention discloses a method for electroplating iridium metal onto the surface of a metallic microelectrode for use in a biomedical prosthetic device, which method comprises:

(a) placing the metallic microelectrode into an aqueous solution of iridium ion of between about 1 and 10 percent by weight; and

(b) electroplating the microelectrode of step (a) using a current of between about 0.5 and 15 milliamps wherein said current is controlled by a current controller. In another aspect the method discloses in step (b) the current is also biased and simultaneously applied in a mode wherein the current is equivalent to an impressed voltage of between about 1.5 and 6.0 volts positive.

In other aspects, the method also includes the following :A-after step (b): (c) conditioning the microelectrode after step (b) by heating at a temperature of between about ambient and 350° C.; B-after step (c): (c-1) optionally subjecting the iridium-coated microelectrode of step to ultrasonic energy in the range of between about 1 and 20,000 hertz for between about 0.1 and 10 minutes in a phosphate buffered saline solution; after step (c-1): (d) conditioning the microelectrode of step (c-1) by storage for between about 6 and 150 hrs. in a physiologically equivalent phosphate buffered saline solution selected under in vitro conditions; D-after step (c-1): (d-1) conditioning the microelectrode of step (b-1) by placing it in vivo and conducting the conditioning in the presence of minor amounts liquid selected from natural body fluids or added synthetic liquids; and E-after step (b): (e) conditioning the microelectrode between about positive 1 and negative 1 volts for between 100 and 10,000 millivolts per second, for between about 1 and 100 cycles to form at least one iridium oxide on the surface of the microelectrode. The invention also discloses the use of these microelectrodes in devices and in microelectrodes and in these devices used in the method of treatment of neurological diseases.

Claims

1. A method for electroplating iridium metal onto the surface of a metallic microelectrode for use in a biomedical prosthetic device, which method comprises:

(a) placing the metallic microelectrode into an aqueous solution of iridium ion of between about 1 and 10 percent by weight iridium; and

(b) electroplating the microelectrode of step (a) using a current of between about 0.5 and 15 milliamperes wherein said current is controlled by a current controller.

2. The method of claim 1 wherein in step (b) the current is also biased and simultaneously applied in a mode wherein the current is equivalent to an impressed voltage of between about 1.5 and 6.0 volts positive.

3. The method of claim 2 wherein after step (b):

(b-1) optionally rinsing the plated electrode with an organic liquid or mixture thereof having from 1 to 10 carbon atoms and a boiling point of between about 35° and

200°

C.

4. The method of claim 3 wherein the method includes after step (b-1):

(c) conditioning the microelectrode after step (b) by heating at a temperature of between about ambient and 350°

C.

5. The method of claim 4 wherein the method includes after step (c):

(c-1) optionally subjecting the iridium-coated microelectrode of step to ultrasonic energy in the range of between about 1 and 10,000 hertz for between about 0.1 and 5 minutes in a phosphate buffered saline solution.

6. The method of claim 5 wherein the method includes after step (c-1):

(d) conditioning the microelectrode of step (c-1) by storage for between about 6 and 150 hrs in a physiologically equivalent phosphate buffered saline solution under in vitro conditions.

7. The method of claim 5 wherein the method includes after step (c-1):

(d-1) conditioning the microelectrode of step (c-1) by placing it in vivo and conducting the conditioning in the presence of minor amounts liquid selected from natural body fluids or added synthetic liquids.

8. The method of claim 2 wherein the method includes after step (b):

(e) conditioning the microelectrode by cycling between the positive and negative gassing voltages at slew rates between about 100 and 10,000 millivolts per second, for between about 1 and 100 cycles to form at least one iridium oxide layer on the surface of the microelectrode.

9. The method of claim 8 wherein the conditioning in step (e) occurring under applied voltage is conducted in vivo, controlled by programmable voltage means, powered by means effective to condition the microelectrode.

10. The method of claim 1 wherein the metallic microelectrode in step (a) consists essentially of platinum, iridium or mixtures thereof, wherein the mixtures are between about 90/10 and 10/90 percent by weight.

11. The method of claim 10 wherein in step (a) the constant controlled current is between about 1 and milliamps.

12. The method of claim 2 wherein the microelectrode in step (a) consists essentially of platinum, iridium or mixtures thereof:

and in step (b) the pulsed current is applied at between 1 hertz about 20 kilohertz with a duty cycle of between about 10 and 90%.

13. The method of claim 4 wherein:

in step (a) the metallic microelectrode comprises platinum, iridium or mixtures thereof;

in step (b) the impressed current is equal to between about 1.5 and 5 volts positive dependent upon the impedence of the base microelectrode; and

in step (c) the microelectrode is heated between about 50 and 325°

C.

14. The method of claim 13 wherein in step (c) the heating is between about 150°

and 200°

C.

15. The method of claim 6 wherein:

in step (a) the metallic microelectrode comprises platinum, iridium or mixtures thereof;

In step (b) the constant current is between about 1 and 11 milliamps and the voltage is between about 4.5 and 5.5 volts; and

in step (d) the microelectrode is conditioned for between 100 and 150 hrs under in vivo conditions.

16. The metallic microelectrode obtained by the method of claim 1.

17. The metallic microelectrode obtained by the method of claim 2.

18. The metallic microelectrode obtained by the method of claim 4.

19. The metallic microelectrode obtained by the method of claim 5.

20. The metallic microelectrode obtained by the method of claim 6.

21. The metallic microelectrode obtained by the method of claim 9.

22. The metallic microelectrode obtained by the method of claim 12.

23. The metallic microelectrode obtained by the method of claim 13.