Adsorbent for .beta..sub.2 -microglobulin and immunoglobulin L-chain

• US 4,721,730 A
• Filed: 05/29/1987
• Issued: 01/26/1988
• Est. Priority Date: 05/30/1986
• Status: Expired due to Term

• Current Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
• Original Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
• Inventors: Ogino, Eiji, Tani, Nobutaka, Furuyoshi, Shigeo
• Primary Examiner(s): Foelak, Morton
• Application Number:
  US07/055,387
• Time in Patent Office: 242 Days
• Field of Search: 521/53, 536/30, 536/56, 436/532, 210/679, 210/692
• US Class Current: 521/53
• CPC Class Codes: B01J 20/28014 characterised by their form
• CPC Class Codes: B01J 20/28047 Gels
• CPC Class Codes: B01J 20/28057 Surface area, e.g. B.E.T specific surface area
• CPC Class Codes: B01J 20/28078 Pore diameter
• CPC Class Codes: B01J 20/3092 Packing of a container, e.g. packing a cartridge or column of chromatography columns B01D15/206
• CPC Class Codes: B01J 20/321 consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3212 consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3219 involving a particular spacer or linking group, e.g. for attaching an active group
• CPC Class Codes: B01J 20/3248 the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
• CPC Class Codes: B01J 20/3255 comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
• CPC Class Codes: B01J 2220/58 Use in a single column

Abstract

An adsorbent for β₂ -microglobulin and immunoglobulin L-chain suitable for use in an extracorporeal circulation treatment, which comprises a porous water-insoluble carrier and a compound immobilized onto said carrier, said compound satisfying that the value of log P, in which P is a partition coefficient in an octanol-water system, is not less than 2.5. The adsorbent is inexpensive, and efficiently adsorb and remove β₂ -microglobulin and immunoglobulin L-chain contained in a body fluid.

Claims

1. An adsorbent for β

₂ -microglobulin and immunoglobulin L-chain suitable for use in an extracorporeal circulation treatment, which comprises a porous water-insoluble carrier, and carrier having molucular weight of the exclusion limit measured with a globular protein from 1×

10⁴ to 6×

10⁵, and a compound immobilized onto said carrier, said compound satisfying that the value of log P, in which P is a partition coefficient in an octanol-water system, is not less than 2.5.

2. The adsorbent of claim 1, wherein said porous water-insoluble carrier is a hydrophilic carrier.

3. The adsorbent of claim 1, wherein said porous water-insoluble carrier is a hard carrier.