Metal-ceramic composite material useful for implant devices

• US 4,722,870 A
• Filed: 01/22/1985
• Issued: 02/02/1988
• Est. Priority Date: 01/22/1985
• Status: Expired due to Fees

• Current Assignee: Interpore International Inc. (Interpore Spine Limited)
• Original Assignee: Interpore International Inc. (Interpore Spine Limited)
• Inventors: White, Eugene W.
• Primary Examiner(s): Zimmerman, John J.
• Application Number:
  US06/692,978
• Time in Patent Office: 1,106 Days
• Field of Search: 164/98, 164/111, 3/1.9, 3/1.91, 3/1.911, 3/1.912, 3/1.913, 264/19, 428/544, 428/304.4, 428/307.7, 428/312.8, 428/409, 428/687, 428/539.5, 433/201, 623/16
• US Class Current: 428/621
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61L 27/04 Metals or alloys
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: Y10T 428/12535 with additional, spatially distinct nonmetal component

Abstract

A material useful as a biomaterial for the manufacture of prosthetic devices and the like is provided by casting a suitable metal, such a Vitallium, into a hydroxyapatite and/or whitlockite investment with three-dimensional interconnected porosity. The resulting composite is finished to expose the investment in order to provide a superior surface for attachment to bone. The composite may be cast as part of the casting of metal prostheses such as hip joints or artificial teeth, in such a way that the investment is present in a thin layer at the desired bone attachment locations.

Claims

1. A synthetic composite material, the structure of which is characterized by two interpenetrating three-dimensional regions, each of said regions being a single, multiply interconnected domain, one of said regions being composed of a metal and the other of said regions being composed of a calcium phosphate.

2. A material in accordance with claim 1 in which said calcium phosphate is hydroxyapatite.

3. A material is accordance with claim 1 in which said calcium phosphate is a mixture of hydroxyapatite and whitlockite.

4. A material in accordance with claim 1 in which said calcium phosphate is whitelockite.

5. A material in accordance with claim 1 in which said metal is an alloy comprising about 56% cobalt, about 35% chromium, and about 5% molybdenum.

6. A material in accordance with claim 1 in which said metal is stainless steel.

7. A material in accordance with claim 1 in which said metal is a cobalt alloy.

8. A material in accordance with claim 1 in which said metal is a titanium alloy.

9. A material in accordance with claim 1 in which said metal is a silver alloy.

10. A material in accordance with claim 1 in which said metal is a gold alloy.

11. A synthetic composite material useful as a biomaterial, the structure of which is characterized by two interpenetrating three-dimensional regions, each of said regions being a single multiple interconnected domain, one of said regions being composed of hydroxyapatite and the other of said regions being composed of a biocompatible metal.

12. A material in accordance with claim 11 in which said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising abut 65% cobalt, about 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

13. A synthetic composite material useful as a biomaterial, the structure of which is characterized by two interpenetrating three-dimensional regions, each of said regions being a single multiply interconnected domain, one of said regions being composed of a mixture of hydroxyapatite and whitlockite, and the other of said regions being composed of a biocompatible metal.

14. The material according to claim 13 in which said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising abut 65% cobalt, about 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

15. A synthetic composite material useful as a biomaterial, the structure of which is characterized by two interpenetrating three-dimensional regions, each of said regions being a single multiply interconnected domain, one of said regions being composed of whitlockite, and the other of said regions being composed of a biocompatible metal.

16. The material according to claim 15 in which said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising about 65% cobalt, about 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

17. A synthetic composite material useful as a biomaterial formed by the casting of a metal into a calcium phosphate investment, said calcium phosphate investment being characterized by a three-dimensional interconnected porosity and by being a single multiply interconnected domain.

18. A material in accordance with claim 17 in which the calcium phosphate of said calcium phosphate investment is hydroxyapatite and said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising about 65% cobalt, about 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

19. A material in accordance with claim 17 in which the calcium phosphate of said calcium phosphate investment is a hydroxyapatite/whitlockite mixture and said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising about 65% cobalt, about 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

20. A material in accordance with claim 17 in which the calcium phosphate investment is whitlockite and said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising 65% cobalt, about 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

21. An implantable surgical or dental prosthesis composed of a synthetic composite material, the structure of said composite material being characterized by two interpenetrating three-dimensional regions, each of said regions being a single multiple interconnected domain, one of said regions being composed of a calcium phosphate and the other of a metal.

22. An implantable surgical or dental prosthesis in accordance with claim 21 in which said calcium phosphate is hydroxyapatite and said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising 65% cobalt, about 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

23. An implantable surgical or dental prosthesis according to claim 22, in which said composite material forms only part of said prosthesis and is present at locations where bone fixation is desired, said composite material being exposed at the surface of said prosthesis at said locations.

24. An implantable surgical or dental prosthesis in accordance with claim 21 in which said calcium phosphate is a hydroxyapatite/whitlockite mixture and said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising about 65% of cobalt, about 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

25. An implantable surgical or dental prosthesis according to claim 24, in which said composite material forms only part of said prosthesis and is present at locations where bone fixation is desired, said composite material being exposed at the surface of said prosthesis at said locations.

26. An implantable surgical or dental prosthesis in accordance with claim 21 in which said calcium phosphate is whitlockite and said metal is selected from the group stainless steel, titanium alloy, cobalt alloy, an alloy comprising about 65% cobalt, 35% chromium, and about 5% molybdenum, silver alloy and gold alloy.

27. An implantable surgical or dental prosthesis according to claim 21, in which said composite material forms only part of said prosthesis and is present at locations where bone fixation is desired, said composite material being exposed at the surface of said prosthesis at said locations.

28. An implantable surgical or dental prosthesis according to claim 27, in which said composite material forms only part of said prosthesis and is present at locations where bone fixation is desired, said composite material being exposed at the surface of said prosthesis at said locations.

29. An implantable surgical or dental prosthesis according to claim 27 in which the surface of said composite material, exposed at said locations where bone fixation is desired, is pitted through selective removal of said calcium phosphate.

30. An implantable surgical or dental prosthesis according to claim 21 in which the surface of said composite material, exposed at said locations were bond fixation is desired, is pitted through selected removal of said calcium phosphate.

31. The process which comprises the steps of preparing a calcium phosphate investment for casting, said calcium phosphate investment having a three-dimensional, interconnected porosity and comprising a single multiply interconnected domain, casting molten metal into said investment, and allowing said metal to solidify so that a metal/calcium phosphate composite material results, and finishing a surface of said resulting metal/calcium phosphate composite material so that said calcium phosphate investment is exposed at said surface.

32. The process according to claim 31 in which the step of finishing comprises the steps of placing, prior to casting, a fine powder resistant to the heat of casting in said porosity of said calcium phosphate investment at a selected surface thereof, to a selected depth from said surface and removing said powder after the solidification of said metal.

33. The process according to claim 32 in which said fine powder is calcium oxide powder.

34. The process which comprises the steps of preparing a calcium phosphate investment for casting, said calcium phosphate investment having a three-dimensional interconnected porosity and comprising a single multiply interconnected domain, casting molten metal into said investment, allowing said metal to solidify so that a metal/calcium phosphate composite material results, finishing a surface of the resulting metal/calcium phosphate composite material so that said calcium phosphate investment is exposed at said surface, and pitting said surface through selective removal of said exposed calcium phosphate investment.