Therapeutical application of phosphonylmethoxyalkyl adenines

• US 4,724,233 A
• Filed: 04/21/1986
• Issued: 02/09/1988
• Est. Priority Date: 04/25/1985
• Status: Expired due to Term

• Current Assignee: Ceskoslovenska akademie ved, Institute Of Organic Chemistry And Biochemistry Of The Ascr, V.V.I., Stichting Rega VZW
• Original Assignee: Ceskoslovenska akademie ved, Stichting Rega VZW
• Inventors: De Clercq, Erik, Holy, Antonin, Rosenberg, Ivan
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US06/854,087
• Time in Patent Office: 659 Days
• Field of Search: 514/81
• US Class Current: 514/81
• CPC Class Codes: A61K 31/675 having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/22 for herpes viruses
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The (S) and (RS) forms of certain phosphonylmethoxyalkyl adenines and their salts have an antiviral effect against several DNA viruses and can be used for the treatment of virus diseases in human and veterinary medicine.

Claims

1. A method for treating virus diseases, which comprises administering to a patient in need of said treatment an effective antiviral amount of a phosphonylmethoxyalkyladenine of the formula (I) ##STR3## wherein R¹ is methylene, --CH(OH)--CH₂ -- or ##STR4## and R² is a hydroxyl group, and, wherein, when R¹ is different from methylene, R¹ and R² may be linked with each other to form a cyclic ester group, said adenine derivative being in (RS) or (S) form when R¹ is different from methylene and further being in the form of a free acid or a salt thereof wherein the salts are selected from the group consisting of alkali metal, ammonia, and amine salts.

2. The method of claim 1, wherein said compound is (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine.

3. The method of claim 1, wherein said virus disease is caused by a herpes virus.

4. A method of claim 1, wherein said virus disease is caused by pox virus.

5. The method of claim 1, wherein said virus disease is caused by a retrovirus.

6. The method of claim 1, wherein said virus disease is caused by reovirus.

7. The method of claim 1, wherein said virus disease is caused by parainfluenza virus.

8. The method of claim 1, wherein said virus disease is caused by sindbis virus.

9. The method of claim 1, wherein said virus disease is caused by polio virus.

10. The method of claim 1, wherein said virus disease is caused by vesicular stomatitis virus.

11. The method of claim 1, wherein said virus disease is caused by vaccinia.

12. The method of claim 1, wherein said virus disease is caused by moloney sarcoma virus.