Apparatus for measuring a chemical entity in a liquid

• US 4,726,929 A
• Filed: 04/21/1987
• Issued: 02/23/1988
• Est. Priority Date: 01/25/1985
• Status: Expired

• Current Assignee: Mallinckrodt Sensor Systems, Inc.
• Original Assignee: Analytix, Inc.
• Inventors: Gropper, Adrian, Sidell, Richard
• Primary Examiner(s): Lacey, David L.
• Assistant Examiner(s): KRYZA, LYNN M
• Application Number:
  US07/041,650
• Time in Patent Office: 308 Days
• Field of Search: 422/68, 422/81, 422/82, 422/100, 422/102, 356/244, 356/246
• US Class Current: 422/82.04
• CPC Class Codes: G01N 35/08 using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis

Abstract

Apparatus for measuring or detecting a chemical entity in a liquid sample, the apparatus including a first module operationally connected to a second module, the first module having a flow passage for the sample, the flow passage including a sensor for measuring or detecting the chemical entity and pump means for advancing the sample along the flow passage, the second module including means for actuating the pump means, and the second module being connected to the first module via connecting means permitting disconnection of the first and second modules and connection of a replacement first module to the second module.

Claims

1. Apparatus for measuring or detecting a chemical entity in a liquid sample, said apparatus comprising a first module operationally connected to a second module,

said first module comprising a flow passage for receiving at least one liquid sample and having reagent containing means, of sufficient size with sufficient reagent to mix with a plurality of samples entering said flow passage to allow for succesive analysis of a plurlaity of samples, and having flushing fluid containing means said flow passage including a sensor section including sensor means for contacting fluid comprising a liquid sample and reagent to measure or detect a chemical entity of the fluid while establishing a noncontaminating relationship with said second module and said first module including pump means for advancing the sample along said flow passage and actuating said flushing fluid containing means, thereby flushing said first module between analysis of successive samples,

said second module comprising means for actuating said pump means,

said second module being connected to said first module via connecting means permitting disconnection of said first module from said second module and connection of a replacement first module to said second module,

and wherein first module is in the form of a sealed disposable cartridge.

2. The apparatus of claim 1 wherein said sensor means of said first module comprises a plurality of different sensors for measuring a plurality of different chemical entities in a sample.

3. The apparatus of claim 1 wherein said pump means is located downstream from said sensor section.

4. The apparatus of claim 1 wherein said first module includes, downstream from said sensor section, a waste chamber for holding a sample after said chemical entity in the sample has been detected or measured.

5. The apparatus of claim 1 wherein said apparatus further comprises at least one reference chamber containing sufficient reference solution for analysis of a plurality of samples.

6. The apparatus of claim 1 wherein said flow passage of said first module includes, upstream from said sensor section, a sample inlet port for introducing the liquid sample into said first module.

7. The apparatus of claim 6 wherein said flow passage includes, downstream from said sample inlet port and upstream from said sensor section, a selector valve for controlling the intake of a sample into said flow passage, and wherein said second module includes means for actuating said selector valve.

8. The apparatus of claim 7 wherein said first module further comprises a holding chamber for holding a calibrating reagent, said holding chamber being connected to said flow passage, and passage of said calibrating reagent into said flow passage being controlled by said selector valve.

9. A replaceable module in the form of a disposable cartridge for use in apparatus for measuring or detecting a chemical entity in a liquid sample that establishes a non-contaminating relationship with said apparatus, said replaceable module comprising a flow passage for receiving at least one liquid sample, and having reagent containing means of sufficient size with sufficient reagent to mix with a plurality of samples entering said flow passage to allow for successive analysis of a plurality of samples, and having a flushing fluid containing means, and wherein said flow passage includes a sensor section including sensor means for contacting fluid comprising a liquid sample and reagent, allowing for measuring or detecting a chemical entity of the fluid, said module including pump means for advancing the sample along said flow passage and actuating said flushing fluid containing means, thereby flushing said module between analysis of successive samples.