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Methods for modulating ligand-receptor interactions and their application

  • US 4,727,022 A
  • Filed: 03/14/1984
  • Issued: 02/23/1988
  • Est. Priority Date: 03/14/1984
  • Status: Expired due to Term
First Claim
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1. A method for modulating complex formation between a receptor and its homologous ligand,said method comprising:

  • combining (a) a receptor having a pair of proximate determinant sites which have the same or different binding specificity and are related in that a change in spatial relationship of the pair of sites relative to each other is related to the interaction capability of said receptor with its homologous ligand, (b) site-directed binding molecules ("SDBM'"'"'s") to said pair of determinant sites on said receptor, wherein said SDBM'"'"'s specifically bind to and bridge said pair of determinant sites and affect the interaction of said receptor with said ligand, with the proviso that when said determinant sites in said pair are not both bound and bridged by a single SDBM, molecules binding specifically to and bridging said SDBM'"'"'s are added to bind and bridge to said SDBM'"'"'s, said binding of said SDBM'"'"'s to and the bridging of said receptor determinant sites thereby modulating the ability of the receptor to bind to said ligand, and (c) said ligand.

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