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Photochemical decontamination treatment of whole blood or blood components

  • US 4,727,027 A
  • Filed: 10/07/1985
  • Issued: 02/23/1988
  • Est. Priority Date: 05/02/1983
  • Status: Expired due to Term
First Claim
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1. A method for decontaminating a blood clotting factor containing composition of viral contaminants, in a manner which substantially maintains the biological activity of the blood clotting factors, said method comprising adding to the blood clotting factor containing composition at least one furocoumarin, and irradiating the furocoumarin containing composition under U-V light, wherein the amount of furocoumarin and irradiation conditions are sufficient to inactivate substantially all the viral contaminants, and wherein the concentration of dissolved oxygen is reduced to a level sufficient to substantially inhibit the denaturation of the blood clotting factors.

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