Ultrafiltration regulation by differential weighing

• US 4,728,433 A
• Filed: 02/02/1984
• Issued: 03/01/1988
• Est. Priority Date: 02/02/1984
• Status: Expired due to Fees

• Current Assignee: Althin Medical, Inc.
• Original Assignee: CD Medical Incorporated
• Inventors: Buck, Robert J., Montgomery, John R., Burbank, John
• Primary Examiner(s): Spear, Frank
• Application Number:
  US06/576,230
• Time in Patent Office: 1,489 Days
• Field of Search: 210/929, 210/86, 210/646, 210/96.2, 210/321.3, 210/85, 210/90
• US Class Current: 210/646
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1611 Weight of the patient
• CPC Class Codes: A61M 1/1643 with weighing of fresh and used dialysis fluid
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir
• CPC Class Codes: Y10S 210/929 Hemoultrafiltrate volume measurement or control processes

Abstract

Hemodialysis ultrafiltration apparatus comprises a hemodialyzer, a supply line for supplying fresh dialysate to the hemodialyzer. A drain line is provided for removing spent dialysate from the hemodialyzer. The dialyzer is adapted to be connected to a patient so that the patient'"'"'s blood may be supplied to and removed from the hemodialyzer. A weighing mechanism allows a fixed amount of fresh dialysate, by weight, to flow through the hemodialyzer. Spent dialysate emerging from the hemodialyzer is then weighed by the weighing device to determine the weight differential therebetween to monitor and control the amount and rate of ultrafiltrate removed from blood in the hemodialyzer.

A method of hemodialytic ultrafiltration is carried out substantially in accordance with the above-described apparatus.

Claims

1. An apparatus for regulating ultrafiltration during hemodialysis comprising:

a hemodialyzer for the dialysis and ultrafiltration of blood including inlet and outlet blood ports, an inlet dialysate port for the entry of fresh dialysate and an outlet dialysate port for the exit of spent dialysate including ultrafiltrate added to the dialysate in the hemodialyzer;

a differential weighing receptacle having an inlet chamber and an outlet chamber, said inlet chamber having a fluid inlet opening for receiving fresh dialysate, and a fluid outlet opening in fluid communication with the inlet dialysate port of said hemodialyzer for the delivery of fresh dialysate to said hemodialyzer, said outlet chamber having a fluid inlet opening in fluid communication with the outlet dialysate port of said hemodialyzer for receiving spent dialysate including any added ultrafiltrate therefrom, and a fluid outlet opening for the draining of dialysate from said outlet chamber;

means for concurrently allowing the inlet chamber to fill with fresh dialysate while spent dialysate is emptied from the outlet chamber and to alternate functions in cyclic fashion; and

weighing means associated with said receptacle for weighing a pre-selected amount of fresh dialysate which fills said inlet chamber when said outlet chamber is substantially empty, and for weighing the amount of spent dialysate and ultrafiltrate associated therewith which fills said outlet chamber when said inlet chamber is substantially empty for determining the difference in weights between fresh dialysate weighed in the inlet chamber and spent dialysate, including ultrafiltrate, weighed in the outlet chamber to thereby monitor and control the amount and rate of ultrafiltrate removed from blood in said hemodialyzer.

2. The apparatus of claim 1 wherein said weighing means includes an adjustable tension spring for determining the weight of said receptacle at any given time and a transducer for converting the force generated by said weight to an electrical signal so that weight levels are ascertainable electrically.

3. The apparatus of claim 2 wherein said transducer is electrically connected to said means for controlling the filling and emptying of said chambers so that the inlet chamber is allowed to fill with fresh dialysate until a pre-selected weight level is reached while said outlet chamber is substantially empty, and thereafter for a short period of time fresh dialysate flow into said inlet chamber and spent dialysate flow out of said outlet chamber are prevented whereby the weight of said spent dialysate can be determined for the control of ultrafiltration of the blood.

4. The apparatus of claim 1 wherein means for controlling the filling of said chambers includes an operable valve and a pump associated with the fluid inlet opening of said inlet chamber and a drain pump associated with the fluid outlet opening of said outlet chamber.

5. The apparatus of claim 4 which further includes a pacer pump associated with the outlet opening of said inlet chamber for pumping fresh dialysate to said hemodialyzer and a pressure pump associated with the inlet opening of said outlet chamber for pumping spent dialysate from said hemodialyzer, said pacer and said pressure pumps being operable to continuously pump fluid through the hemodialyzer.

6. The apparatus of claim 1 which further includes means for determining and displaying the ultrafiltration rate and the amount of ultrafiltrate removed from the blood during each weighing cycle and for regulating the amount of ultrafiltrate removed from the blood in a specified time by controlling the ultrafiltration rate based on the amount of ultrafiltrate remaining to be removed and the amount of time remaining in the pre-determined weighing cycle.

7. Hemodialysis ultrafiltration apparatus comprising:

hemodialysis means;

means for supplying fresh dialysate to and for removing spent dialysate, including ultrafiltrate, from said hemodialysis means;

means for supplying and removing blood from said hemodialysis means; and

differential weighing receptacle means for allowing a first amount of fresh dialysate, by weight, to flow into said hemodialysis means and for weighing a second amount of spent dialysate flowing out of said hemodialysis means corresponding thereto, said means further comprising means for determining from the weight differential between the first and second amounts of dialysate the amount and rate of ultrafiltrate removed from the blood in said hemodialysis means.

8. A method for regulating ultrafiltration during hemodialysis comprising:

supplying blood to and removing blood from a hemodialyzer;

supplying fresh dialysate to an inlet chamber of a differential weighing receptacle and concurrently removing spent dialysate from an outlet chamber of said receptacle;

weighing said fresh dialysate in said receptacle, and, upon reaching a pre-selected weight level when said outlet chamber is substantially empty, preventing the further flow of fresh dialysate into said inlet chamber;

allowing only said fixed amount of fresh dialysate, by weight, to flow through said hemodialyzer;

collecting spent dialysate including ultrafiltrate, emerging from said hemodialyzer into said outlet chamber and weighing it over a time period not greater than the time period for said fixed amount of dialysate to flow through said hemodialyzer;

determining the weight differential between said fixed amount of fresh dialysate and said spent dialysate to monitor and control the amount and rate of ultrafiltrate removed from blood in the hemodialyzer.

9. The method of claim 8 wherein the dialysate supplying and removing steps are cyclically repeated so that the regulation of ultrafiltration is continuous.

10. The method of claim 8 wherein fresh dialysate is continuously supplied to and spent dialysate is continuously removed from said hemodialyzer during hemodialysis.

11. The method of claim 8 wherein weight differentials are determined only during the time period when spent dialysate emerging from said hemodialyzer, based on said fixed amount of fresh dialysate, is being collected.

12. The method of claim 8 which further includes determining and displaying the ultrafiltration rate and the amount of ultrafiltrate removed from the blood during the weighing period.

13. The method of claim 12 which further includes regulating the amount of ultrafiltrate removed from the blood in a specified time by controlling the ultrafiltration rate based on the amount of ultrafiltrate remaining to be removed and the amount of time remaining in the weighing cycle.

14. A method of hemodialytic ultrafiltration comprising:

supplying fresh dialysate to and removing spent dialysate, including ultrafiltrate, from hemodialysis means;

supplying and removing blood from said hemodialysis means;

periodically allowing a known amount of fresh dialysate, by weight, to flow into said hemodialysis means;

periodically weighing with a differential weighing receptacle means the amount of spent dialysate associated with said known amount which flows out of said hemodialysis means; and

determining the weight differential between the known amount of fresh dialysate and the associated amount of spent dialysate so as to allow the amount and rate of ultrafiltrate removed from the blood in said hemodialysis means to be monitored and controlled.