Calcium-hydroxide-treated polymeric implant matrial

• US 4,728,570 A
• Filed: 10/29/1985
• Issued: 03/01/1988
• Est. Priority Date: 10/29/1985
• Status: Expired due to Term

• Current Assignee: United States Surgical Corporation (Medtronic Plc)
• Original Assignee: United States Surgical Corporation (Medtronic Plc)
• Inventors: Ashman, Arthur, Binderman, Itzhak
• Primary Examiner(s): Swisher, Nancy A. B.
• Application Number:
  US06/792,352
• Time in Patent Office: 854 Days
• Field of Search: 623/16, 623/10, 428/323, 428/327, 428/330, 427/2, 128/92 YG, 128/92 YQ
• US Class Current: 428/327
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61K 6/887 Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate
• CPC Class Codes: Y10T 428/254 Polymeric or resinous material
• CPC Class Codes: Y10T 428/258 Alkali metal or alkaline earth metal or compound thereof

Abstract

An implant material for hard tissue comprising a porous matrix of a mass of biologically-compatible polymeric particles, the particles bonded together to form a unitary prosthetic implant, the prosthetic implant having interstices between the bonded particles forming pores into which bone tissue can grow and having a quantity of calcium hydroxide distributed in the pores of the matrix. Also disclosed is a packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising a mass of disjoint polymeric particles having an inner core and an outer coating and a quantity of calcium hydroxide distributed in the mass of polymeric particles effective to induce hard tissue growth.

Claims

1. An implant material for hard tissue, the implant material comprising a porous matrix comprised of a mass of biologically-compatible polymeric particles, the particles being bonded together to form a unitary prosthetic implant, the prosthetic implant having interstices between the bonded particles forming pores into which bone tissue can grow and a quantity of calcium hydroxide distributed in the pores of the matrix, the pores having dimensions effective to permit the growth of bone tissue into the pores, the quantity of calcium hydroxide being effective to induce the growth of bone tissue in the pores.

2. The implant material according to claim 1 in which each of said biologically-compatible polymeric particles has an inner core comprised of a first biologically-compatible polymeric material and has an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second material being hydrophilic and having a composition different from the composition of the first polymeric material.

3. The implant material according to claim 2 in which the first polymeric material is an acrylic polymer.

4. The implant material according to claim 3 in which the first polymeric material is polymethylmethacrylate.

5. The implant material according to claim 3 in which the second polymeric material is a polymeric hydroxyethylmethacrylate.

6. The implant material according to claim 5 in which the polymeric hydroxyethylmethacrylate comprises a copolymer of monomeric hydroxyethylmethacrylate and a cross-linking agent.

7. The implant material according to claim 5 in which the prosthetic implant is shaped to form a tooth root.

8. The implant material according to claim 5 in which the prosthetic implant is shaped to form section of bone.

9. The implant material according to claim 8 in which the prosthetic implant is shaped to form a section of jawbone.

10. The implant material according to claim 1 further including a radiopaque material.

11. The implant material according to claim 10 in which the radiopaque material is barium sulfate.

12. The implant material according to claim 1 in which the pores have a size of from about 350 to about 415μ

m.

13. A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising:

(a) a mass of disjoint polymeric particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, the particles being of a size to permit the mass of the disjoint particles to be packed in a body cavity to form a prosthetic implant for hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow; and

(b) a quantity of calcium hydroxide distributed in the mass of polymeric particles, the quantity of calcium hydroxide being effective to induce the growth of hard tissue in the pores of the mass of the particles when packed in a body cavity.

14. The packing material of claim 13 in which the diameter of the polymeric particles is in the range of from about 590 to about 840 μ

m.

15. The packing material of claim 14 in which the first polymeric material is an acrylic polymer.

16. The packing material of claim 15 in which the first polymeric material is polymethylmethacrylate.

17. The packing material of claim 15 in which the second polymeric material is a polymeric hydroxyethylmethacrylate.

18. The packing material according to claim 13 in which the calcium hydroxide forms a coating on outer surfaces of the polymeric particles.

19. The packing material according to claim 18 in which the coating of calcium hydroxide on the polymeric particles is formed by wetting the mass of polymeric particles with an aqueous solution of calcium hydroxide and then allowing the solution to dry.

20. The packing material according to claim 19 in which the concentration of calcium hydroxide in the calcium hydroxide solution is in the range of from about 0.05 to about 1 percent by weight.

21. A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising:

(a) a mass of disjoint biologically-compatible polymeric particles, the particles being of a size to permit the mass of the disjoint particles to be packed in a body cavity to form a prosthetic implant for hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow; and

(b) a quantity of calcium hydroxide coated on the outer surfaces of said biologically-compatible polymeric particles, the quantity of calcium hydroxide being effective to induce the growth of hard tissue in the pores of the mass of the particles when packed in a body cavity.

22. The packing material according to claim 21 wherein the biologically-compatible polymeric particles are comprised of an acrylic polymer.

23. The packing material according to claim 22 wherein the acrylic polymer is polymethylmethacrylate.