Method of treating wounds with granules and dressing

• US 4,728,642 A
• Filed: 04/29/1985
• Issued: 03/01/1988
• Est. Priority Date: 04/22/1982
• Status: Expired due to Term

• Current Assignee: E R Squibb & Sons Incorporated
• Original Assignee: E R Squibb & Sons Incorporated
• Inventors: Pawelchak, John M., Freeman, Frank M.
• Primary Examiner(s): Brown, J. R.
• Assistant Examiner(s): Peselev, Elli
• Application Number:
  US06/728,421
• Time in Patent Office: 1,037 Days
• Field of Search: 514/54, 514/57, 514/59, 514/60, 514/2
• US Class Current: 514/57
• CPC Class Codes: A61F 13/0209 comprising superabsorbent material
• CPC Class Codes: A61F 13/0213 the fluid retention member being a layer of hydrocolloid, gel forming material
• CPC Class Codes: A61F 13/022 having more than one layer with different fluid retention characteristics
• CPC Class Codes: A61F 13/0226 characterised by the support layer
• CPC Class Codes: A61F 13/0253 characterized by the adhesive material
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids

Abstract

This invention is directed to an occlusive dressing useful for treating skin lesions and a granular material capable of interacting with wound exudate. Wounds emitting a large amount of fluid can be treated by first packing with the granular material and then covering the wound with the occlusive dressing.

Claims

1. The method of treating a dermal ulcer emitting a large amount of exuadate comprising packing the ulcer with granules capable of interacting with the exudate and then overlaying the ulcer with an occlusive dressing having an adhesive layer which also is capable of reacting with the exudate and of forming a bond with the normal skin surrounding said ulcer wherein said granules have a particle size of from about 10 to about 40 mesh and consist essentially of one or more water dispersible hydrocolloids selected from the group consisting of sodium carboxymethylcellulose, calcium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, collagen and gum karaya, and from zero to 50% by weight of one or more water swellable cohesive strengthening agents, one or more hydratable polymers, and mixtures thereof wherein said water swellable cohesive strengthening agents if present are selected from the group consisting of water-insoluble cross-linked sodium carboxymethylcellulose, water-insoluble starch-acrylonitrile graft copolymer, and water-insoluble cross-linked dextran and wherein said hydratable polymers if present are selected from the group consisting of gluten and long chain polymers of methyl vinyl ether/maleic acid and wherein said occulusive dressing is a multi-layered dressing consisting essentially of an adhesive layer which in use contacts the wound and the surrounding normal skin, an intermediate layer of semi-open cell polymeric foam bonded to the upper surface of said adhesive layer, and an outer moisture impervious polymeric film coated or laminated to the upper surface of said foam layer, wherein said wound and skin contacting adhesive layer consists of from about 35% to about 50% by weight of low molecular weight polyisobutylenes and from about 45% to about 65% by weight of one or more water dispersible hydrocolloids selected from the group consisting of sodium carboxymethylcellulose, calcium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, collagen, and gum karaya.

5. The method of claim 1 wherein said wound and skin contacting adhesive layer is a homogeneous blend of about 40% by weight of low molecular weight polyisobutylene, about 20% by weight of sodium carboxymethylcellulose, about 20% by weight of pectin, and about 20% by weight of gelatin.

6. The method of claim 5 wherein said semi-open cell polymeric foam is polyurethane foam and said water impervious polymeric film is polyurethane.

7. The method of claim 6 wherein said wound and skin contacting adhesive layer is from about 0.02 to about 0.1 inches in thickness, said polyurethane foam layer is about 0.03 to about 0.1 inchs in thickness, and said water impervious polyurethane layer is about 0.001 to about 0.003 inches in thickness.

2. The method of treating a dermal ulcer emitting a large amount of exudate comprising packing the ulcer with granules capable of interacting with the exudate and then overlaying the ulcer with an occlusive dressing having an adhesive layer which also is capable of reacting with the exudate and of forming a bond with the normal skin surrounding said ulcer wherein said granules have a particles size of from about 10 to about 40 mesh and consists of an equal weight percent mixture of pectin, gelatin, and sodium carboxymethylcellulose and said occlusive dressing is a multi-layered dressing consisting essentially of an adhesive layer which in use contacts the wound and the surrounding normal skin, said adhesive layer being from about 0.02 to about 0.1 inches in thickness, an intermediate layer of semi-open cell polyurethane foam bonded to the upper surface of said adhesive layer, said foam layer being from about 0.03 to about 0.1 inches in thickness, and an outer moisture impervious polyurethane film coated or laminated to the upper surface of said foam layer, said film being from about 0.001 to about 0.003 inches in thickness, wherein said wound and skin contacting adhesive layer is a homogeneous blend of about 40% by weight of low molecular weight polyisobutylene, about 20% by weight of sodium carboxymethylcellulose, about 20% by weight of pectin, and about 20% by weight of gelatin.

3. The method of treating a dermal ulcer emitting a large amount of exudate comprising packing the ulcer with granules capable of interacting with the exudate and then overlaying the ulcer with an occlusive dressing having an adhesive layer which also is capable of reacting with the exudate and of forming a bond with the normal skin surrounding said ulcer wherein said granules have a particle size of from about 10 to about 40 mesh and consist essentially of one or more water dispersible hydrocolloids selected from the group consisting of sodium carboxymethylellulose, calcium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, collagen and gum karaya, and from zero to 50% by weight of one or more water swellable cohesive strengthening agents, one or more hydratable polymers, and mixtures thereof wherein said water swellable cohesive strengthening agents if present are selected from the group consisting of water-insoluble cross-linked sodium carboxymethylcellulose, water-insoluble starch-acrylonitrile graft copolymer, and water-insoluble cross-linked dextran and wherein said hydratable polymers if present are selected from the group consisting of gluten and long chain polymers of methyl vinyl ether/maleic acid and wherein said occlusive dressing is a multi-layered dressing consisting essentially of a first adhesive layer which in use contacts the wound and the surrounding normal skin, a second adhesive layer bonded to the top surface of said first adhesive layer, an intermediate layer of semi-open cell polymeric foam bonded to the upper surface of said second adhesive layer, and an outer moisture impervious polymeric film coated or laminated to the upper surface of said foam layer, wherein said first adhesive layer consists of from about 35% to about 50% by weight of low molecular weight polyisobutylene and from about 45% to about 65% by weight of one or more water dispersible hydrocolloids selected from the group consisting of sodium carboxymethylcellulose, calcium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, collagen, and gum karaya and wherein said second adhesive layers consists of from about 35% to about 50% by weight of low molecular weight polyisobutylenes and one or more optional thermoplastic elastomers selected from the group consisting of medium molecular weight polyisobutylenes, butylenes, butyl rubber, aand styrene-isoprene-stryrene copolymers, from about 30% to about 50% by weight of one or more water dispersible hydrocolloids selected from the group consisting of sodium carboxymethylcellulose, calcium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, collagen, and gum karaya, from about 5% to about 15% by weight of mineral oil, from about 15% to about 25% by weight of a terpene resin tackifier, and less than about 5% by weight of one or more anti-oxidants, deodorants, and perfume agents.

8. The method of claim 3 wherein said wound and skin contacting adhesive layer is a homogenous blend of about 40% by weight of low molecular weight polyisobutylene, about 20% by weight of sodium carboxymethylcellulose, about 20% by weight of pectin, and about 20% by weight of gelatin.

9. The method of claim 8 wherein said second adhesive layer is a homogeneous blend of from about 18% by weight of low molecular weight polyisobutylenes, about 20% by weight of medium molecular weight polyisobutylenes, about 18% by weight of sodium carboxymethylcellulose, about 15% by weight of gelatin, about 20% by weight of terpene resin, about 8.5% by weight of mineral oil, and about 0.5% by weight of butylated hydroxytoluene.

10. The method of claim 9 wherein said semi-open cell polymeric foam is polyurethane foam and said water impervious polymeric film is polyurethane.

11. The method of claim 10 wherein said wound and skin contacting adhesive layer is from about 0.02 to about 0.1 inches in thickness, said second adhesive layer is from about 0.005 to about 0.02 inches in thickness said polyurethane foam layer is about 0.03 to about 0.1 inches in thickness, and said water impervious polyurethane layer is about 0.001 to about 0.003 inches in thickness.

4. The method of treating a dermal ulcer emitting a large amount of exudate comprising packing the ulcer with granules capable of interacting with the exudate and then overlaying the ulcer with an occulusive dressing having an adhesive layer which also is capable of reacting with the exudate and of forming a bond with the normal skin surrounding said ulcer wherein said granules have a particle size of from about 10 to about 40 mesh and consist of an equal weight percent mixture of pectin, gelatin, and sodium carboxymethylcellulose and said occulusive dressing is a multi-layered dressing consisting essentially of a first adhesive layer which in use contacts the wound and the surrounding normal skin, said first adhesive layer being of from about 0.02 to about 0.1 inches in thickness, a second adhesive layer bonded to the top surface of said first adhesive layer, said second adhesive layer being from about 0.005 to about 0.02 inches in thickness, an intermediate layer of semi-open cell polyurethane foam bonded to the upper surface of said second adhesive layer, said foam being from about 0.03 to about 0.1 inches in thickness, and an outer moisture impervious polyurethane film coated or laminatred to the upper surface of said foam layer, said film being from about 0.001 to about 0.003 inches in thickness, wherein said wound and skin contacting first adhesive layer is a homogenous blend of about 40% by weight of low molecular weight polyisobutylene, about 20% by weight of sodium carboxymethylcellulose, about 20% by weight of pectin, and about 20% by weight of gelatin, and wherein said second adhesive layer is a homogeneous blend of from about 18% by weight of low molecular weight polyisbutylenes, about 20% by weight of medium molecular weight polyisobutylenes, about 18% by weight of sodium carboxymethylcellulose, about 15% by weight of gelatin, about 20% by weight of terpene resin, about 8.5% by weight of mineral oil, and about 0.5% by weight of butylated hydroxytoluene.