Ultra - rapid plasma freezing with halocarbon heat transfer liquids
First Claim
1. A process of freezing plasma comprising the steps of exposing thin wall containers of plasma to be frozen to direct contact with a heat transfer liquid selected from the group consisting of the chlorofluorocarbon 1,1,2 trichloro-1,2,2 trifluoro-ethane (CFC 113) and mixtures of the chlorofluorocarbon 1,1,2 trichloro-1,2,2 trifluoro-ethane (Freon 113), and at least one of the fluorocarbons perfluoropentane (C5 F12), perfluorohexane (C6 F14), perfluoromethylcyclohexane (C7 F14), perfluoroheptane (C7 F16), perfluoromonomethyldimethylcyclohexanes (C7 F14 /C8 F16), perfluorodecalin isomers (C10 F18), mixed perfluorodecalin and methyldecalin isomers (C10 F18 +C11 F20), and perfluorinated polyethers ([OCF(CF3)CF2 ]n --(OCF2)m, and maintaining said liquid at a temperature sufficiently low enough to freeze said plasma in the desired amount of time.
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Accused Products
Abstract
Ultra rapid freezing of thin wall containers, preferably plastic bags or bottles, of blood plasma by direct contact with a low freezing temperature liquid mixture of a chlorofluorocarbon (CFC 113) and at least one of a group of fluorocarbons minimizes migration of toxins in the heat transfer liquid to the plasma and improves the percentage yield of blood soluble protein fractions extracted from the frozen plasma in a subsequent freeze drying process.
27 Citations
7 Claims
- 1. A process of freezing plasma comprising the steps of exposing thin wall containers of plasma to be frozen to direct contact with a heat transfer liquid selected from the group consisting of the chlorofluorocarbon 1,1,2 trichloro-1,2,2 trifluoro-ethane (CFC 113) and mixtures of the chlorofluorocarbon 1,1,2 trichloro-1,2,2 trifluoro-ethane (Freon 113), and at least one of the fluorocarbons perfluoropentane (C5 F12), perfluorohexane (C6 F14), perfluoromethylcyclohexane (C7 F14), perfluoroheptane (C7 F16), perfluoromonomethyldimethylcyclohexanes (C7 F14 /C8 F16), perfluorodecalin isomers (C10 F18), mixed perfluorodecalin and methyldecalin isomers (C10 F18 +C11 F20), and perfluorinated polyethers ([OCF(CF3)CF2 ]n --(OCF2)m, and maintaining said liquid at a temperature sufficiently low enough to freeze said plasma in the desired amount of time.
Specification