Drug delivery system

• US 4,731,058 A
• Filed: 05/22/1986
• Issued: 03/15/1988
• Est. Priority Date: 05/22/1986
• Status: Expired due to Fees

• Current Assignee: Sims Deltec, Inc.
• Original Assignee: Pharmacia Deltec, Inc. (Smiths Group International Holdings Ltd.)
• Inventors: Doan, Phong D.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Lewis, Ralph
• Application Number:
  US06/865,687
• Time in Patent Office: 663 Days
• Field of Search: 128/DIG. 1, 128/DIG. 12, 604/153, 604/154, 604/155, 604/131, 604/191, 604/245, 604/246, 222/23, 222/55, 222/63, 222/333
• US Class Current: 604/155
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: Y10S 128/01 Motorized syringe

Abstract

A system for delivering a drug to a patient according to the preferred embodiment of the present invention is shown as including a plunger assembly reciprocally received in a reservoir for forcing the drug therefrom for delivery to the patient. The plunger assembly is axially advanced by the rotation of a lead screw rotatably mounted and axially movable with respect to the chassis. In a first axial position, the end of the lead screw deflects contacts of a switch member into electrical engagement which interrupts operation of the motor which rotates the lead screw. The lead screw is biased out of its first axial position such that the first end of the lead screw does not actuate the switch member and rotation of the lead screw is not interrupted. An increase in the force necessary to advance the plunger assembly into the reservoir due to excessive reservoir back pressure caused by occlusion, plunger assembly friction, a depleted reservoir, and like conditions will cause the lead screw to move into its first axial position against its bias and to actuate the switch member.

Claims

1. System for delivering a drug to a patient including a reservoir for storing the drug to be delivered to the patient by the system and a plunger assembly reciprocally received in the reservoir for forcing the drug to the patient from the reservoir when advanced into the reservoir, with the plunger assembly having a free end, comprising, in combination:

a chassis;

a lead screw having a first end;

means for mounting the lead screw for rotation and at least limited axial movement from a first axial position with respect to the chassis;

a motor having an output shaft;

means for rotatably relating the output shaft of the motor with the lead screw for rotating the lead screw with respect to the chassis;

a drive nut threadably received on the lead screw and removeably attached in a nonrotatable manner to the free end of the plunger assembly for advancing the plunger assembly in the reservoir in response to the rotation of the lead screw by the motor and the rotatably relating means; and

switch means actuated by the first end of the lead screw for electrically interrupting the operation of the motor when the lead screw is moved into its first axial position as the result of an increase of force necessary to advance the plunger assembly into the reservoir due to excessive reservoir back pressure caused by occlusion, plunger assembly friction, a depleted reservoir, and like conditions, with the switch means including means for axially biasing the lead screw with respect to the chassis out of its first axial position and in the direction of axial movement of the plunger assembly for advancing the plunger assembly into the reservoir for forcing the drug from the reservoir.

2. The drug delivery system of claim 1 wherein the switch means comprises, in combination:

a first contact held in a spaced relation from the chassis; and

a second contact in a normally spaced condition from the first contact, with the first end of the lead screw abutting with the second contact in its first axial position and moving the second contact to electrically engage the first contact.

3. The drug delivery system of claim 2 wherein the second contact comprises a spring contact for axially biasing the lead screw with respect to the chassis out of its first axial position and in the direction of axial movement of the plunger assembly for advancing the plunger assembly into the reservoir for forcing the drug from the reservoir.

4. The drug delivery system of claim 3 further comprising in combination:

means for providing a preset thrust threshold before the second, spring contact electrically engages the first contact.

5. The drug delivery system of claim 4 wherein the preset thrust threshold providing means comprises a spacer located intermediate the second, spring contact and the chassis.

6. The drug delivery system of claim 3 further comprising, in combination:

means for adjusting the amount of the increase of force necessary to interrupt the operation of the motor by the switch means.

7. The drug delivery system of claim 6 wherein the adjusting means comprises, in combination:

means for adjusting the spacing of the first contact from the chassis.

8. The drug delivery system of claim 7 wherein the spacing adjusting means comprises a set screw threadably received in the chassis and abutting with the first contact for adjusting the spacing between the chassis and the first contact and between the first and second contacts.

9. The drug delivery system of claim 1 wherein the rotatably relating means includes a gear slidably mounted and rotatably fixed to the lead screw;

and wherein the drug delivery system further comprises, in combination;

a wave-spring washer located between the chassis and the lead screw gear.

10. System for delivering a drug to a patient including a reservoir for storing the drug to be delivered to the patient by the system and a plunger assembly reciprocally received in the reservoir for forcing the drug to the patient from the reservoir when advanced into the reservoir comprising, in combination:

a chassis;

a lead screw having a first end;

means for mounting the lead screw for rotation and at least limited axial movement from a first axial position with respect to the chassis, with the lead screw being axially biased with respect to the chassis out of its first axial position and in the direction of axial movement of the plunger assembly for advancing the plunger assembly into the reservoir for forcing the drug from the reservoir;

means for rotating the lead screw with respect to the chassis;

means for axially advancing the plunger assembly with respect to the reservoir acting in cooperation with the lead screw and its rotation produced by the rotating means; and

means actuated by the first end of the lead screw for interrupting the operation of the rotating means when the lead screw is moved into its first axial position against the bias of the lead screw as the result of an increase of force necessary to advance the plunger assembly into the reservoir due to excessive reservoir back pressure caused by occlusion, plunger assembly friction, a depleted reservoir, and like conditions.

11. The drug delivery system of claim 10 wherein the operation interrupting means comprises, in combination:

switch means actuated by the first end of the lead screw for electrically interrupting of the rotating means.

12. The drug delivery system of claim 11 wherein the switch means comprises, in combination:

a first contact held in a spaced relation from the chassis; and

a second contact in a normally spaced condition from the first contact, with the first end of the lead screw abutting with the second contact in its first axial position and moving the second contact to electrically engage the first contact.

13. The drug delivery system of claim 12 wherein the second contact comprises a spring contact for axially biasing the lead screw with respect to the chassis out of its first axial position and in the direction of axial movement of the plunger assembly for advancing the plunger assembly into the reservoir for forcing the drug from the reservoir.

14. The drug delivery system of claim 13 further comprising, in combination:

means for providing a preset thrust threshold before the second contact electrically engages the first contact comprising a spacer located intermediate the second, spring contact and the chassis.

15. The drug delivery system of claim 13 further comprising, in combination:

means for adjusting the amount of the increase of force necessary to interrupt the operation of the rotating means by the interrupting means.

16. The drug delivery system of claim 15 wherein the adjusting means comprises, in combination:

means for adjusting the spacing of the first contact from the chassis.

17. The drug delivery system of claim 16 wherein the spacing adjusting means comprises a set screw threadably received in the chassis and abutting with the first contact for adjusting the spacing between the chassis and the first contact and between the first and second contacts.

18. The drug delivery system of claim 10 wherein the rotating means includes a gear slideably mounted and rotatably fixed to the lead screw;

and wherein the drug delivery system further comprises, in combination;

a wave-spring washer located on the lead screw between the chassis and the lead screw gear.

19. The drug delivery system of claim 18 wherein the rotating means comprises, in combination:

a motor having an output shaft; and

gearing means for rotatably relating the output shaft of the motor with the lead screw gear, with at least limited axial movement being allowed between the lead screw gear and the gearing means.

20. The drug delivery system of claim 10 further comprising, in combination:

means for adjusting the amount of the increase of force necessary to interrupt the operation of the rotating means by the interrupting means.

21. In a system for delivering a drug to a patient including a reservoir for storing the drug to be delivered to the patient by the system and a plunger assembly reciprocally received in the reservoir for forcing the drug to the patient from the reservoir when advanced into the reservoir, a chassis, and means for axially advancing the plunger assembly into the reservoir, with the axially advancing means having a first end mounted for at least limited axial movement from a first axial position with respect to the chassis, with the improvement comprising switch means actuated by the first end of the axially advancing means for electrically interrupting the axially advancing means comprising, in combination:

a first contact held in a spaced relation from the chassis; and

a second, spring contact in a normally spaced condition from the first contact, with the first end of the axially advancing means abutting with the second, spring contact in its first axial position and moving the second, spring contact to electrically engage the first contact, with the second, spring contact axially biasing the axially advancing means with respect to the chassis out of its first axial position and in the direction of axial movement of the plunger assembly for advancing the plunger assembly into the reservoir for forcing the drug from the reservoir, with the switch means electrically interrupting the axially advancing means when the first end is moved into its first axial position against the bias of the second, spring contact as the result of an increase of force necessary to advance the plunger assembly into the reservoir due to excessive reservoir back pressure caused by occlusion, plunger assembly friction, a depleted reservoir, and like conditions.

22. The drug delivery system of claim 21 further comprising, in combination:

means for providing a preset thrust threshold before the second, spring contact electrically engages the first contact.

23. The drug delivery system of claim 22 wherein the preset thrust threshold providing means comprises, in combination:

a spacer located intermediate the second, spring contact and the chassis.

24. The drug delivery system of claim 21 further comprising, in combination:

means for adjusting the amount of the increase of force necessary to electrically interrupt the axially advancing means by the switch means.

25. The drug delivery system of claim 24 wherein the adjusting means comprises, in combination:

means for adjusting the spacing of the first contact from the chassis.

26. The drug delivery system of claim 25 wherein the spacing adjusting means comprises a set screw threadably received in the chassis and abutting with the first contact for adjusting the spacing between the chassis and the first contact and between the first contact and the second, spring contact.

27. The drug delivery system of claim 21 wherein the axially advancing means comprises, in combination:

a lead screw;

means for mounting the lead screw for rotation and at least limited axial movement with respect to the chassis;

means for rotating the lead screw with respect to the chassis; and

means for axially advancing the plunger assembly with respect to the reservoir acting in cooperation with the lead screw and its rotation produced by the rotating means.

28. The drug delivery system of claim 27 wherein the first end is located ont he lead screw.

29. The drug delivery system of claim 27 wherein the rotating means includes a gear slideably mounted and rotatably fixed to the lead screw;

and wherein the drug delivery system further comprises, in combination;

a wave-spring washer located on the lead screw between the chassis and the lead screw gear.

30. The drug delivery system of claim 29 wherein the rotating means comprises, in combination:

a motor having an output shaft; and

gearing means for rotatably relating the output shaft of the motor with the lead screw gear, with at least limited axial movement being allowed between the lead screw gear and the gearing means.

31. The drug delivery system of claim 21 wherein the second, spring contact has a first, secured end secured to the chassis and a second, free end, with the the second, spring contact electrically engaging the first contact adjacent to its second, free end, with the first end of the axially advancing means abutting with the second, spring contact intermediate its first, secured end and its second, free end to allow a leverage advantage to be obtained.