Coated intraocular lens

• US 4,731,080 A
• Filed: 05/20/1986
• Issued: 03/15/1988
• Est. Priority Date: 01/18/1985
• Status: Expired due to Term

• Current Assignee: Miles A. Galin
• Original Assignee: Miles A. Galin
• Inventors: Galin, Miles A.
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): Cannon, Alan W.
• Application Number:
  US06/865,381
• Time in Patent Office: 665 Days
• Field of Search: 623/6, 623/66, 502/158, 427/2, 427/54.1, 427/93, 522/100, 525/531, 351/160 R, 351/160 H
• US Class Current: 623/6.57
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: A61F 2/1613 having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue of bone tissue onto implantable joints A61F2002/30932
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/21 Acids
• CPC Class Codes: A61L 2300/232 Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

An improved intraocular lens is coated with a non-smudging biologically compatible hydrophobic crosslinked vinyl-containing silicone polymer coating material, such as polymethylvinyl siloxane or polymethylphenylvinyl siloxane. The coating material is inert, does not smudge upon contact with another surface, reduces damage on contact with the intraocular tissue, particularly the endothelium, and prevents intraocular lens induction of inflammation. The coating material or matrix preferably contains at least one optically compatible medicament which can be gradually and controllably released therefrom with time and which makes the lens suitable for implantation in both the phakic and aphakic eye. The coating material may further contain a small amount of fine particle size fumed silica.

Claims

1. An intraocular lens coated with a non-smudging biologically compatible hydrophobic crosslinked vinyl-containing silicone polymer coating material selected from the group consisting of polymethylvinyl siloxane and polymethylphenylvinyl siloxane.

2. An intraocular lens defined by claim 1 wherein the coating material contains at least one optically compatible medicament which can be gradually and controllably released therefrom with time and which makes the lens suitable for implantation in both the phakic and aphakic eye.

3. An intraocular lens defined by claims 1 or 2 wherein the coating constitutes from about 0.001% to about 20% by weight of the intraocular lens.

4. An intraocular lens defined by claims 1 or 2 wherein the coating has a thickness of from about 10 Å

to about 10⁶ Å

.

5. An intraocular lens defined by claim 2 wherein the medicament constitutes from about 0.001% to about 20% by weight of the coating material.

6. An intraocular lens defined by claim 1 wherein the hydrophobic crosslinked vinyl-containing silicone polymer coating material is polymethylvinyl siloxane.

7. An intraocular lens defined by claim 1 wherein the hydrophobic crosslinked vinyl-containing silicone polymer coating material is polymethylphenylvinyl siloxane.

8. An intraocular lens defined by claim 2 wherein the medicament is an anticoagulant.

9. An intraocular lens defined by claim 2 wherein the medicament is an antiinflammatory agent.

10. An intraocular lens defined by claim 2 wherein the medicament is an anticomplement agent.

11. An intraocular lens defined by claim 2 wherein the medicament is an antibacterial agent.

12. An intraocular lens defined by claim 2 wherein the medicament is ethacrylic acid.

13. An intraocular lens defined by claim 2 wherein the coating material also contains a sulfated polysaccharide.

14. An intraocular lens defined by claim 13 wherein the sulfated polysaccharide is heparin having a molecular weight of from about 12,000 to about 15,000 daltons.

15. An intraocular lens defined by claim 13 wherein the sulfated polysaccharide is low molecular weight heparin having a molecular weight of from about 2,500 to about 5,300 daltons.

16. An intraocular lens defined by claim 13 wherein the sulfated polysaccharide is dextran sulfate.

17. An intraocular lens defined by claim 13 wherein the sulfated polysaccharide is chondroitin sulfate.

18. An intraocular lens defined by claim 13 wherein the sulfated polysaccharide is chitosan sulfate.

19. An intraocular lens defined by claim 13 wherein the sulfated polysaccharide is xylan sulfate.

20. An intraocular lens defined by claim 13 wherein the sulfated polysaccharide is a hyaluronate.

21. An intraocular lens defined by claims 1 or 2 wherein the coating material contains a small amount of fine particle size fumed silica.

22. An intraocular lens defined by claim 21 wherein the coating material contains an amount up to about 20% by weight of the coating material of fumed silica particles having an average particle size of about 12 nanometers.