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Method of manufacturing disposable and/or replenishable transdermal drug applicators

  • US 4,731,926 A
  • Filed: 12/10/1985
  • Issued: 03/22/1988
  • Est. Priority Date: 02/19/1985
  • Status: Expired due to Term
First Claim
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1. A method of manufacturing a transdermal drug applicator which is adapted to be electrically activated, comprising the steps of:

  • (a) applying conductive coated areas to the first surface of flexible, non-conductive substrate having first and second surfaces for use in said drug applicator, said coated areas and said substrate forming a one-piece member;

    (b) folding by about 180 degree portions of said one-piece member with said conductive coated areas so as to form folded top side and bottom side portions and to provide electrical conductors leading between said top side and bottom side portions;

    (c) applying at least one occlusive adhesive dam to the surface of another substrate containing thereon a coated release agent;

    (d) adding at least one drug resrvoir to said surface of said another substrate adjacent to said dam;

    (e) joining said at least one drug reservoir to a portion of at least one of said coated areas of said electrical conductors;

    (f) joining together in registration said bottom side of said one-piece member and said another substrate to form a sandwiched construction in which said at least one drug reservoir and said occlusive dam are contained between bottom side of said one-piece member and said another substrate;

    (g) applying a conformal cover having an adhesive coated surface over said second side of said flexible substrate of said folded one-piece member so as to enclose and protect said transdermal drug applicator.

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