Method of manufacturing disposable and/or replenishable transdermal drug applicators
First Claim
1. A method of manufacturing a transdermal drug applicator which is adapted to be electrically activated, comprising the steps of:
- (a) applying conductive coated areas to the first surface of flexible, non-conductive substrate having first and second surfaces for use in said drug applicator, said coated areas and said substrate forming a one-piece member;
(b) folding by about 180 degree portions of said one-piece member with said conductive coated areas so as to form folded top side and bottom side portions and to provide electrical conductors leading between said top side and bottom side portions;
(c) applying at least one occlusive adhesive dam to the surface of another substrate containing thereon a coated release agent;
(d) adding at least one drug resrvoir to said surface of said another substrate adjacent to said dam;
(e) joining said at least one drug reservoir to a portion of at least one of said coated areas of said electrical conductors;
(f) joining together in registration said bottom side of said one-piece member and said another substrate to form a sandwiched construction in which said at least one drug reservoir and said occlusive dam are contained between bottom side of said one-piece member and said another substrate;
(g) applying a conformal cover having an adhesive coated surface over said second side of said flexible substrate of said folded one-piece member so as to enclose and protect said transdermal drug applicator.
1 Assignment
0 Petitions
Accused Products
Abstract
Applicators for the electrophoretic and/or electro-osmotic deposition of a medicament across the skin and into the blood stream. The applicator includes a plurality of drug reservoir electrodes, a battery, a plurality of folded members each having an electrically conductive coating on a flexible, non-conductive substrate in electrical contact with the batttery and the drug reservoir electrodes, electrical current conditioning means, a cover adhesively secured to the applicator, and a release liner covering and protecting the drug reservoirs until use. A method of manufacturing the applicator is set forth.
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Citations
32 Claims
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1. A method of manufacturing a transdermal drug applicator which is adapted to be electrically activated, comprising the steps of:
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(a) applying conductive coated areas to the first surface of flexible, non-conductive substrate having first and second surfaces for use in said drug applicator, said coated areas and said substrate forming a one-piece member; (b) folding by about 180 degree portions of said one-piece member with said conductive coated areas so as to form folded top side and bottom side portions and to provide electrical conductors leading between said top side and bottom side portions; (c) applying at least one occlusive adhesive dam to the surface of another substrate containing thereon a coated release agent; (d) adding at least one drug resrvoir to said surface of said another substrate adjacent to said dam; (e) joining said at least one drug reservoir to a portion of at least one of said coated areas of said electrical conductors; (f) joining together in registration said bottom side of said one-piece member and said another substrate to form a sandwiched construction in which said at least one drug reservoir and said occlusive dam are contained between bottom side of said one-piece member and said another substrate; (g) applying a conformal cover having an adhesive coated surface over said second side of said flexible substrate of said folded one-piece member so as to enclose and protect said transdermal drug applicator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 31, 32)
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12. A method for making a replaceable disposable drug reservoir for a transdermal drug applicator adapted to be electrically powered, comprising the steps of:
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a. providing a release coated substrate; b. depositing on said substrate a plurality of occlusive adhesive dams made of a nonconductive material impervious to fluids to define a plurality of drug reservoir compartments; c. laminating an open cell foam material to said substrate over said occlusive adhesive dams so as to cause said nonconductive material to penetrate and fill the full thickness of said open cell foam; and d. filling said plurality of drug reservoir compartments with various gelled drug mixtures. - View Dependent Claims (13, 14)
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29. A method of manufacturing a transdermal drug applicator which is electrically activated, comprising the steps of:
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a. applying conductive coated areas to one surface of a plastic substrate for use in said drug applicator; b. folding by about 180°
portions of said conductive coated areas so as to provide electrical conductors leading to the other surface side of the drug applicator plastic substrate;c. applying at least one occlusive adhesive dam to a surface of another substrate containing thereon a coated release agent; d. adding at least one drug reservoir to said surface of said another substrate in areas not occupied by said occlusive adhesive dam; e. applying at least one drug reservoir to a portion of at least one of said electrical conductors; f. joining together in registration said plastic substrate and said another substrate to form a sandwiched construction in which said drug reservoirs and said occlusive adhesive dam are contained between said two substrates; and g. applying a conformal cover having an adhesive coated surface over the folded plastic substrate so as to enclose and protect said transdermal drug applicator. - View Dependent Claims (30)
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Specification