Electrical transdermal drug applicator

• US 4,734,090 A
• Filed: 07/18/1986
• Issued: 03/29/1988
• Est. Priority Date: 07/18/1986
• Status: Expired due to Term

• Current Assignee: Drug Delivery Systems Incorporated
• Original Assignee: Drug Delivery Systems Incorporated
• Inventors: Sibalis, Dan
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Citrin, Randy
• Application Number:
  US06/888,151
• Time in Patent Office: 620 Days
• Field of Search: 128/783, 128/798, 128/799, 128/803, 604/20, 604/21
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

A transdermal drug applicator for passing at least one drug for delivery to the systemic circulation system of a patient through the skin. The applicator includes a drug applicator containing a colloidal suspension having at least one drug for delivery to the body of a patient, the colloidal suspension comprising a fluid medium and generally large, as compared to the size of molecules, particles in the fluid medium. The particles and the medium are of different permittivities. The drug reservoir is capable of being placed in electrical contact with the skin of the patient. A voltage device imposes electrostatic field lines upon the fluid medium so as to create a non-uniform electrostatic field in the fluid medium when the drug reservoir is placed on the skin. The particles migrate in accordance with the principle of dielectrophoresis so as to pass through the skin into the systemic circulation system.

Claims

1. A transdermal applicator system for passing at least one drug for delivery to the systemic circulation system of a patient through the skin having a plurality of sweat ducts opening at the stratum corneum, comprising, in combination,

a drug reservoir containing a colloidal suspension having at least one drug for delivery to the body of the patient, said colloidal suspension comprising a fluid medium and generally large, as compared to the size of molecules, particles in said medium, said medium and said particles being of different permittivities, said reservoir being capable of being placed in electrical contact with the skin of the patient,

voltage means for imposing electrostatic field lines upon said medium so as to create a non-uniform electrostatic field in said medium when said drug reservoir is placed on the skin,

said particles migrating in accordance with the principle of dielectrophoresis so as to pass through the skin into the systemic circulation system.

2. The transdermal applicator system described in claim 1, wherein said particles are water-based drug particles and said fluid medium is an oily fluid medium.

3. The transdermal applicator system described in claim 2, wherein said reservoir includes a skin side capable of being placed in electrical contact with the skin of the patient and an opposed side, and said voltage means includes a permanently polarized electret having opposed poles, one pole being connected with said opposed side, said electret imposing said electrical field lines in said medium between said opposed side and said skin side, said electrostatic field lines converging at the sweat ducts at the stratum corneum so as to create a non-uniform electrostatic field in said medium, whereby said water-based drug particles are moved along the electrostatic field lines into the seat ducts from where said drug particles are absorbed into the body when said skin side of said reservoir is placed in contat with the skin of the patient.

4. The transdermal applicator system described in claim 3, wherein the other pole of said electret is connected with said skin via the stratum corneum side of said reservoir.

5. The transdermal applicator system described in claim 4, further including an electrode capable of being in electrical contact with the skin of the patient and an electrostatic field conductor connecting said other pole of said electret with said electrode.

6. The transdermal applicator system described in claim 5, further including insulation means for precluding short-circuiting of said electret.

7. The transdermal applicator system described in claim 6, wherein said electret has a high internal charge sufficient to impose said electrostatic field lines upon said medium.

8. The transdermal drug applicator system described in claim 3, wherein said drug reservoir is a plurality of drug reservoirs.

9. The transdermal drug reservoir system described in claim 2, wherein said reservoir includes a skin side capable of being placed in electrical contact with the skin of the patient and an opposed side, said voltage means includes a battery having terminals, and an electrode capable of being connected to the skin of the patient, one of said terminals of said battery being electrically connected to said opposed side and the other of said terminals being connected to said electrode, wherein an electrical circuit is created when the skin side of the reservoir and the electrode are placed in contact with the skin of the patient, said battery imposing said electrostatic field lines in said medium between said opposed side and said skin side, said electrostatic field lines converging at the sweat ducts at the stratum corneum so as to create a non-uniform electrostatic field in said medium, whereby the water-based drug particles are moved along the electrostatic field lines into the sweat ducts from where the drug particles are absorbed into the body when the skin side of the reservoir and the electrode are placed in contact with the skin of the patient.

10. The transdermal drug applicator system described in claim 9, wherein said battery is a DC/DC converter.

11. The transdermal drug applicator system described in claim 9, wherein said battery is a DC/AC converter.

12. The transdermal drug applicator system described in claim 9, wherein said electrode is a second drug reservoir containing said colloidal suspension wherein said particles of said second drug reservoir are water-based drug particles and said fluid medium of said second drug reservoir is an oily fluid medium.

13. The transdermal applicator system described in claim 12, wherein said drug reservoir and said second drug reservoir include a plurality of drug reservoirs.

14. The transdermal drug system described in claim 2, wherein said drug reservoir includes a skin side capable of being placed in electrical contact with the skin of the patient and an opposed side, and further including a second drug reservoir including a second skin side capable of being placed in electrical contact with the skin of the patient and a second opposed side, said second drug reservoir containing a solution having a second drug;

said voltage means including a battery having terminals and a permanently polarized electret having poles, one of said terminal of said battery being connected to said second opposed side of said second reservoir; and

an electrode connected to one of said poles of said electret and adapted to be connected to the skin, the other pole of said electret being connected to said opposed side of said drug reservoir;

said electret imposing said electrostatic field lines in said medium of said drug reservoir between said opposed side and said skin side, said electrostatic field lines converging at the sweat ducts at the stratum corneum so as to create a non-uniform electrostatic field in said medium, whereby said water-based drug particles are moved along the electrostatic field lines into the sweat ducts from where said drug particles are absorbed into the body; and

an electrical circuit is created between the battery and the drug reservoir and the second reservoir so that delivery of the second drug from the second reservoir is accomplished when the skin side of the drug reservoir and the skin side of said second reservoir are placed in contact with the skin of the patient.

15. The transdermal drug applicator system described in claim 14, wherein said one terminal is the negative terminal and said other terminal is the positive terminal wherein the current moves in the electrical circuit from said battery to said electrode to said drug reservoir and through the skin to the skin side of said second reservoir.

16. The transdermal drug applicator system described in claim 15, further including another electrode capable of being in electrical contact with the skin of the patient and an electrostatic field conductor connecting the other pole of said electret with said another electrode.

17. The transdermal drug applicator system described in claim 16, said electret having positive and negative sides, said positive side being connected to said electrode and said negative side being connected to said another electrode.

18. The transdermal applicator system described in claim 17, further including insulation means for precluding short-circuiting of said electret.

19. The transdermal drug application system described in claim 2, wherein said reservoir means includes a skin side capable of being placed in electrical contact with the skin of the patient and an opposed side, and further including a second drug reservoir including a second skin side capable of being placed in electrical contact with the skin and a second opposed side, said second drug reservoir containing a second colloidal suspension having at least one drug for delivery to the body of the patient, said second colloidal suspension comprising a second fluid medium and generally large, as compared to the size of molecules, second particles in said second medium, said second medium and said second particles being of different permittivities;

said voltage means including a battery having terminals and a permanently polarized electret having poles, one of said terminals of said battery being connectd to said second opposed side of said second reservoir; and

an electrode connected to one of said poles of said electret and capable of being connected to the skin;

the other pole of said electret being connected to said opposed side of said drug reservoir;

said electret imposing said electrostatic field lines in said medium of said drug reservoir between said opposed side and said skin side said electrostatic field lines converging at the sweat ducts at the stratum corneum so as to create a non-uniform electrostatic field in said medium;

said battery imposing electrostatic field lines in said second medium of said second drug reservoir between said second opposed side and said second skin side, said electrostatic field lines converging at the sweat ducts at the stratum corneum so as to create a non-uniform electrostatic field in said second medium;

whereby said particles and said second particles are moved along the electrostatic field lines into the sweat ducts from where said particles and said second particles are absorbed into the body; and

an electrical circuit is created between the battery and the drug reservoir and the second drug reservoir so that delivery of the second drug from the second reservoir is accomplished when the skin side of the drug reservoir and the skin side of the second drug reservoir are placed in contact with the skin of the patient.

20. The transdermal drug applicator system described in claim 1, wherein said particles are oil-based drug particles and said medium is a water medium.

21. The transdermal drug applicator system described in claim 20, further including an electrode capable of being connected to the skin of the patient, and wherein said reservoir includes a skin side capable of being placed in electrical contact with the skin of the patient and an opposed side, and said voltage means includes a battery having terminals, one of said terminals being connected to said opposed side and the other of said terminals being connected to said electrode, wherein an electrical circuit is created when the skin side of the reservoir and the electrode are placed in contact with the skin of the patient, said battery imposing said electrostatic field lines in said medium between said opposed side and said skin side, said electrostatic field lines converging at the sweat ducts at the stratum corneum so as to create a non-uniform field in said medium, whereby the oil-basic drug particles are moved along the electrostatic field lines into the sweat ducts from where the drug particles are absorbed into the body when the skin side of the reservoir and the electrode are placed in contact with the skin of the patient until the electrical resistance at the sweat ducts approximates the electrical resistance at the stratum corneum at which time electrical current passes throughout the stratum corneum and a quasi-uniform field is created in the reservoir and drug delivery is accomplished through the stratum corneum until the drug in the sweat ducts is absorbed and a non-uniform field is established in the reservoir and drug delivery is again accomplished through the sweat ducts.

22. The transdermal drug applicator system described in claim 21, wherein said one terminal is the positive terminal and said other terminal is the negative terminal.

23. The transdermal drug applicator system described in claim 22, wherein said electrode is a second drug reservoir containing said colloidal suspension wherein said particles of said second drug reservoir are water-based drug particles and said fluid medium of said second drug reservoir is an oily fluid medium.

24. The transdermal drug applicator system described in claim 23, wherein said drug reservoir and said second drug reservoir include a plurality of drug reservoirs.

25. The transdermal drug applicator system described in claim 1, wherein said particles are oil-based particles and said medium is a water-based drug fluid medium.

26. The transdermal drug applicator system described in claim 25, wherein said reservoir includes a skin side capable of being placed in electrical contact with the skin of a patient and an opposed side said voltage means includes a battery having terminals, and an electrode capable of being connected to the skin of the patient, one of said terminals of said battery being electrically connected to said opposed side and the other of said terminals being connected to said electrode, wherein an electrical circuit is created when the skin side of the reservoir and the electrode are placed in contact with the skin of the patient, said battery imposing said electrostatic field lines in said medium between said opposed side and said skin side, said electrostatic field lines converging at the sweat ducts at the stratum corneum so as to create a non-uniform electrostatic field in said medium, whereby the water-based drug fluid medium migrates into the body when the skin side of the reservoir and the electrode are placed in contact with the skin of the patient.

27. The transdermal drug applicator system described in claim 26, wherein said battery is a DC/DC converter.

28. The transdermal applicator system described in claim 27, wherein said battery is a DC/AC converter.

29. The transdermal drug applicator system described in claim 26, wherein said electrode is a second drug reservoir containing said colloidal suspension wherein said particles of said second drug reservoir are oil-based particles and said fluid medium of said second drug reservoir is a water-based drug fluid medium.