Method for inhibiting bone resorption and collagenase release

• US 4,735,945 A
• Filed: 03/13/1986
• Issued: 04/05/1988
• Est. Priority Date: 03/13/1986
• Status: Expired due to Fees

• Current Assignee: Vipont Pharmaceutical, Inc. (Colgate-Palmolive Company)
• Original Assignee: Vipont Laboratories Incorporated
• Inventors: Sakamoto, Masako, Sakamoto, Seizaburo
• Primary Examiner(s): Robinson, Douglas W.
• Application Number:
  US06/839,229
• Time in Patent Office: 754 Days
• Field of Search: 514/279, 514/900
• US Class Current: 514/279
• CPC Class Codes: A61K 31/47 Quinolines; Isoquinolines

Abstract

Method of inhibiting bone resorption and collagenase release in mammalian periodontal subjects using a benzo-c-phenanthridine alkaloid compound.

Claims

1. A method of inhibiting bone resorption and collagenase activity in mammals having periodontal disease, comprising adminstering to said mammals in amount from about 0.2 to about 20 umol/L of sanguinarine, sanguinarine pseudoethanolate or mixtures thereof dissolved in dimethylsulfoxide.

2. The method of claim 1 wherein said sanguinarine is administered in amounts from about 1 to about 20 umol/L.

3. The method of claim 1 wherein sanguinarine pseudoethanolate is administered in amounts from about 0.2 to about 20 umol/L.

4. The method of claim 2 wherein sanguinarine is administered in amount of 20 umol/L.

5. The method of claim 4 wherein sanguinarine pseudoethanolate is administered in amounts of 5 umol/L.