Process for preparing salt of hyaluronic acid with a pharmaceutically active substance
First Claim
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1. A process for the preparation of a salt of hyaluronic acid with a pharmaceutically active substance which comprises:
- (a) combining an aqueous solution of a barium salt of hyaluronic acid with a sulfate of a pharmaceutically active substance; and
(b) separating the precipitated barium sulfate to obtain the salt of hyaluronic acid with a pharmaceutically active substance in aqueous solution.
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Abstract
Pharmaceutical preparations for topical administration containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
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15 Claims
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1. A process for the preparation of a salt of hyaluronic acid with a pharmaceutically active substance which comprises:
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(a) combining an aqueous solution of a barium salt of hyaluronic acid with a sulfate of a pharmaceutically active substance; and (b) separating the precipitated barium sulfate to obtain the salt of hyaluronic acid with a pharmaceutically active substance in aqueous solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A process for the preparation of a barium salt of hyaluronic acid or a molecular weight fraction thereof which comprises
(a) treating a cetylpyridinium salt of hyaluronic acid or a molecular weight fraction thereof with an aqueous solution of barium chloride; - and
(b) separating the aqueous solution and adding ethanol to thereby precipitate the barium salt of hyaluronic acid or of a molecular weight fraction thereof. - View Dependent Claims (14, 15)
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Specification