Irradiation chamber for photoactivation patient treatment system

• US 4,737,140 A
• Filed: 05/22/1987
• Issued: 04/12/1988
• Est. Priority Date: 10/29/1984
• Status: Expired due to Term

• Current Assignee: McNeilab, Inc. (Johnson & Johnson)
• Original Assignee: McNeilab, Inc. (Johnson & Johnson)
• Inventors: Lee, Kyu H., King, Martin J., Troutner, Vernon H., Goss, Jack
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Kartchner, Gene B.
• Application Number:
  US07/054,114
• Time in Patent Office: 326 Days
• Field of Search: 128/DIG. 3, 210/321.2, 210/321.4, 210/321.5, 210/646
• US Class Current: 604/6.08
• CPC Class Codes: A61M 1/3616 Batch-type treatment
• CPC Class Codes: A61M 1/36222 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/36224 with sensing means or components thereof
• CPC Class Codes: A61M 1/36225 with blood pumping means or components thereof
• CPC Class Codes: A61M 1/362261 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/362262 Details of incorporated reservoirs
• CPC Class Codes: A61M 1/362266 Means for adding solutions or substances to the blood
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3683 using photoactive agents
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 2205/051 with radiation therapy
• CPC Class Codes: A61M 2209/082 Mounting brackets, arm supports for equipment
• CPC Class Codes: Y10S 128/03 Heart-lung

Abstract

A removable U.V. light array assembly for use in a photoactivatable agent, patient treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.

Claims

1. A flat plate irradiation chamber, for use in a patient treatment system for altering cells, including treating the cells with a photoactivatable agent and passing the cells and the agent through a field of photoactivating radiation whereby said agent is caused to be activated and to affect said cells, said agent and said cells being contained in the irradiation chamber during irradiation, said flat plate irradiation chamber comprising:

a rigid top sheet matably joined with a rigid bottom sheet, forming therebetween a rigid serpentine pathway for conducting said cells through said field of radiation; and

pump block means for holding tubing means in fluid communication with said serpentine pathway and adapted for engaging a peristaltic pump whereby rotation of the pump causes said cells to flow through said serpentine pathway, and wherein said chamber is removable from said system and disposable.

2. The chamber of claim 1 wherein at least one of said sheets is substantially transparent to said photoactivating radiation.

3. The chamber of claim 2 which further comprises means for preventing creeping movement of said tubing means during rotation of said peristaltic pump when said pump block means is engaged therewith.

4. The chamber of claim 2 further comprising memory means for providing information characteristic of said chamber to said patient treatment system.

5. The chamber as described in claim 4 further comprising sensor probe means in thermal communication with said fluid for providing an output in response to fluid temperature.

6. The chamber of claim 4 further comprising means for receiving urging force from said patient treatment system for engaging said pump block means with said peristaltic pump.

7. The chamber of claim 4 wherein said memory means is selected from the group consisting of integrated circuit having a non-volatile memory, integrated circuit having a power source, and magnetic memory means.

9. The chamber of claim 1, wherein the cells are presented to the irradiation in a serpentine pathway having a large surface area to volume ratio thereby reducing cellular self-shielding effects.

10. The chamber of claim 1, wherein the top and bottom sheets are male and female thin plate sections bonded together in sealing arrangement.

11. The chamber of claim 1, wherein the pump block is molded as part of the serpentine pathway.

12. The chamber of claim 1, wherein the pump block is separately mounted to the serpentine pathway.

13. The chamber of claim 1, wherein after mating, the distance between the top and bottom sheets is about 0.04 inches.

14. The chamber of claim 1, wherein the rigid plates are polycarbonate.

8. An irradiation chamber for use in a system for treating blood, comprising:

a serpentine portion comprising two flat, closely spaced apart rigid plates having walls therebetween defining a rigid serpentine pathway between the plates, having an inlet and an outlet, said outlet in flow communication with flexible tubing; and

a pump block, integral with said serpentine portion for containing said tubing, comprising a pump track along which is emplaced said tubing for pumping engagement with a pump when said irradiation chamber is inserted into said system;

whereby said irradiation chamber may be inserted into said system without the need for a separate step to establish flow communication between the inlet of said serpentine chamber and said flexible tubing and wherein said irradiation chamber may be removed from the system together with all blood contacting elements.

15. In combination, a system for treating blood and an irradiation chamber for use therein, wherein:

said system comprises a pump, means for treating blood and means for receiving the chamber; and

said chamber comprises a rigid top sheet matably joined with a rigid bottom sheet, forming therebetween a serpentine pathway for conducting said blood; and

pump block means for holding tubing means in fluid communication with said serpentine pathway and adapted for engaging a peristaltic pump whereby rotation of the pump causes said blood to flow through said serpentine pathway, and wherein said chamber is removable from said system and disposable.

16. The combination of claim 15, wherein the blood in the serpentine pathway has a large surface area to volume ratio.

17. The combination of claim 15, wherein the top and bottom sheets of the chamber are male and female thin, plate sections bonded together in sealing arrangement.

18. The combination of claim 15, wherein the distance between the top and bottom sheets after mating is about 0.04 inches.

19. The combination of claim 15, wherein the rigid sheets are polycarbonate.