Controlled release formulation and method
First Claim
1. A controlled release formulation from which a drug selected from the group consisting of angiotensin converting enzyme inhibitors and ascorbic acid is released at a substantially controlled rate in environments which are neutral or acidic consisting of a reactive matrix of from about 5 to about 80 percent by weight of said drug in combination with from about 5 to about 70 percent by weight of poly[(1→
- 4)-2-amino-2-deoxy-β
-glucose].
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Accused Products
Abstract
In accordance with the present invention, a controlled release formulation is provided from which a drug, selected from the group consisting of angiotensin converting enzyme inhibitors and ascorbic acid, is released at a substantially controlled rate. The controlled release formulation of the invention is comprised of a reactive matrix of from about 5 to about 80 percent by weight of the drug in combination with from about 5 to about 70 percent by weight of poly[(1→4)-2-amino-2-deoxy-β-D-glucose] (also referred to as chitosan herein). Further in accordance with the present invention there is provided a gel-like complex formed of the drug and the chitosan in environments ranging from neutral to acidic.
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Citations
20 Claims
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1. A controlled release formulation from which a drug selected from the group consisting of angiotensin converting enzyme inhibitors and ascorbic acid is released at a substantially controlled rate in environments which are neutral or acidic consisting of a reactive matrix of from about 5 to about 80 percent by weight of said drug in combination with from about 5 to about 70 percent by weight of poly[(1→
- 4)-2-amino-2-deoxy-β
-glucose]. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 14, 15, 16, 17, 18, 19, 20)
- 4)-2-amino-2-deoxy-β
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9. A sustained release tablet formulation consisting of from about 5 to about 80 percent by weight of a drug, selected from angiotensin converting enzyme inhibitors and ascorbic acid, in combination with from about 5 to about 70 percent by weight of poly [(1→
- 4)-2-amino-2-deoxy-β
-glucose], from about 0 to about 30 percent by weight of a diluent and from about 0.3 to about 8 percent by weight of a lubricant. - View Dependent Claims (10, 11, 12, 13)
- 4)-2-amino-2-deoxy-β
Specification