NMR blood vessel imaging method and apparatus

• US 4,739,766 A
• Filed: 08/18/1986
• Issued: 04/26/1988
• Est. Priority Date: 08/18/1986
• Status: Expired due to Fees

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Riederer, Stephen J.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Smith, Ruth S.
• Application Number:
  US06/897,597
• Time in Patent Office: 617 Days
• Field of Search: 128/653, 324/306, 324/307, 324/309
• US Class Current: 600/413
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/5673 Gating or triggering based on a physiological signal other than an MR signal, e.g. ECG gating or motion monitoring using optical systems for monitoring the motion of a fiducial marker

Abstract

High speed selective imaging of blood vessels is accomplished by subjecting an area of interest to a plurality of short repetition time NMR pulse sequences during each high velocity period and low velocity period of a heart beat cycle for several or more heart beats. The imaging data from each NMR pulse sequence is collected and weighted according to whether it corresponds to a high velocity period or a low blood velocity period. The weighted imaging data corresponding to high blood velocity periods is then subtracted from weighted imaging data corresponding to low blood velocity periods and the resulting data used to form an image which depicts only the blood vessels of interest. Also, an imaging data processing apparatus is disclosed which operates in real time so as to permit an operator to optimize diagnostic performance.

Claims

1. A high speed method of forming computed images of blood vessels based on measurements of characteristics of a body comprising the steps of:

subjecting a predetermined body area containing blood vesesls of interest to, successively, a plurality of applications of a short repetition time (TR) NMR pulse sequence during the period of high blood velocity and then to a corresponding plurality of said applications during the period of low blood velocity for a plurality of successive heart beat cycles wherein each application during said period of high blood velocity corresponds to a different phase encoding and said sequence of phase encodings is substantially repeated during said period of low blood velocity and collecting data from which an image of the blood vessels can be formed;

weighting the collected imaging data from each application of the NMR pulse sequence according to whether the data was acquired during the period of high blood velocity or a period of low blood velocity of the corresponding heart beat cycle;

accumulating weighted imaging data from a plurality of NMR pulse sequences corresponding to high blood velocit;

y periods and from a plurality of NMR pulse sequences corresponding to low blood velocity periods;

subtracting said weighted imaging data corresponding to each specific phase encoding acquired during the high blood velocity periods from said weighted imaging data for the same phase encoding corresponding to low blood velocity periods in order to compute blood vessel imaging data; and

forming an image of the blood vessels of interest from said blood vessel imaging data.

2. A method according to claim 1 wherein the NMR pulse sequence is a limited flip angle pulse sequence.

3. A method according to claim 2 wherein said limited flip angle is about 30°

.

4. A method according to claim 1 wherein TR times are in the range of about 10-100 msec.

5. A method according to claim 1 wherein 128 individual phase encodings are acquired during high velocity periods and 128 individual phase encodings are acquired during low velocity periods.

6. A method according to claim 1 wherein each high velocity and each low velocity period of a heart beat cycle is subjected to about 10 applications of an NMR pulse sequence.

7. A method according to claim 1 wherein an image of the selected blood vessels can be obtained in about 5 to 20 seconds.

8. A method according to claim 1 wherein said subtracting step includes assigning said accumulated weighted imaging data to respective strips in Fourier space and taking a two-dimensional inverse Fourier transform of said strips.

9. A method according to claim 1 wherein said blood vessel image is displayed in real time on a video monitor.

10. A high speed method of forming computed images of blood vessels based on measurements of NMR characteristics of a body comprising the steps of:

subjecting a predetermined body area containing blood vessels of interest to a plurality of applications of 2 variants of a short repetition time (TR) NMR pulse sequence, said variants devised such that images of static structure will appear substantially identical and images of moving structures will not, said plurality of applications being applied, successively, during the high blood velocity period of a heart beat cycle and then during the low blood velocity period of a heart beat cycle for each of a plurality of successive heart beat cycles, and collecting signal data from which images can be formed;

applying each of said 2 variants of each of said plurality of applications of an NMR pulse sequence at each of a plurality of separate phase encodings;

subtracting at each separate phase encoding said signal data measured from application of one of two said variants of said NMR pulse sequence from signal data measured from application of the other variant of said NMR pulse sequence in order to compute blood vessel imaging data; and

forming an image of the blood vessels of interest from said blood vessel imaging data.

11. A method according to claim 10 wherein said NMR pulse sequence is a limited flip angle.

12. A method according to claim 11 wherein said limited flip angle is about 30°

.

13. A method according to claim 10 wherein TR times are in the range of about 10-100 msec.

14. A method according to claim 10 wherein an image of the selected blood vessels can be obtained in about 5 to 20 seconds.

15. An NMR imaging system for constructing and displaying real time images of selected blood vessels of interest which are derived from NMR measurements comprising:

means for monitoring the cardiac period;

means for performing NMR measurements on blood vessels using, successively, a plurality of applications of a short repetition time (TR) NMR pulse sequence during the high blood velocity period of a heart beat cycle and then a plurality of said applications during the low blood velocity period for a plurality of succesive heart beat cycles, wherein each application during said period of high blood velocity corresponds to a different phase encoding and said sequence of phase encodings is substantially repeated during said period of low blood velocity, said pulse sequences each having a TR time of about 10-100 milliseconds;

means for calculating and storing NMR measurement data and blood pressure data after each pulse sequence to generate imaging data, said means for calculating and storing serving to manipulate parameters including imaging data, encoded phase, and cardiac period;

means for computing an average of previous successive imaging data contribution and adding each new imaging data contribution thereto to provide updated imaging data; and

means for successively constructing and displaying blood vessel images based on said updated imaging data, said images being displayed on a real time basis.

16. An NMR imaging system according to claim 15 wherein said cardiac period monitoring means comprises an electrocardiograph.

17. An NMR imaging system according to claim 15 wherein said cardiac period monitoring means comprises an optical plethysmograph.

18. An NMR imaging system according to claim 15 wherein said cardiac period monitoring means comprises an ultrasonic pulse detector.

19. An NMR imaging system according to claim 15, wherein said means for calculating and storing includes means for subtracting NMR measurement data corresponding to the high blood velocity period of a plurality of heart beat cycles from data corresponding to the low blood velocity period of a plurality of heart beat cycles in order to cancel all image measurement data not corresponding to the blood vessels of interest.

20. An NMR imaging system according to claim 15 wherein said means for constructing and displaying includes a video monitor for displaying said real time images.