Antihyperlipidemic amine boranes

• US 4,740,504 A
• Filed: 02/05/1987
• Issued: 04/26/1988
• Est. Priority Date: 10/08/1985
• Status: Expired due to Fees

• Current Assignee: United States Borax & Chemical Corporation
• Original Assignee: United States Borax & Chemical Corporation
• Inventors: Docks, Edward L., Brotherton, Robert J., Hall, Iris H.
• Primary Examiner(s): Meyers, Albert T.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/011,178
• Time in Patent Office: 446 Days
• Field of Search: 568/1, 514/64, 546/13
• US Class Current: 514/64
• CPC Class Codes: A61K 31/69 Boron compounds

Abstract

Trialkylamine borane compounds are useful as antihyperlipidemic agents for lowering serum cholesterol and triglyceride levels in mammals.

Claims

1. The method of controlling hyperlipidemia in mammals which comprises administering to said mammal an effective amount of an amine borane of the formula ##STR2## in which R represents a lower alkyl of 1 to 4 carbon atoms, and

R¹ represents a higher alkyl group having 4 to about 20 carbon atoms.

2. The method according to claim 1 in which said amine borane is N-n-octadecyl-N,N-dimethylamine borane.

3. The method according to claim 1 in which said amine borane is N-n-hexyl-N,N-dimethylamine borane.

4. The method according to claim 1 in which said amine borane is N-benzyl-N,N-dimethylamine borane.

5. The method according to claim 1 in which both R groups represent methyl.

6. The method according to claim 1 in which said amine borane is administered at a dosage of from about 4 to about 20 mg./kg./day.

7. The method according to claim 2 in which said amine borane is administered at a dosage of about 8 mg./kg./day.

8. The method according to claim 1 in which said amine borane is N-octyl-N,N-dimethylamine borane.

9. The method according to claim 1 in which said amine borane is N-n-butyl-N,N-dimethylamine borane.

10. The method according to claim 1 in which said amine borane is N-decyl-N,N-dimethylamine borane.

11. The method according to claim 1 in which said amine borane is N-tridecyl-N,N-dimethylamine borane.