Dermal and transdermal patches having a discontinuous pattern adhesive layer

• US 4,743,249 A
• Filed: 06/10/1987
• Issued: 05/10/1988
• Est. Priority Date: 02/14/1986
• Status: Expired due to Fees

• Current Assignee: Ciba-Geigy Corporation (Novartis Ag)
• Original Assignee: Ciba-Geigy Corporation (Novartis Ag)
• Inventors: Loveland, Frederic D.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Kartchner, Gene B.
• Application Number:
  US07/061,024
• Time in Patent Office: 335 Days
• Field of Search: 604/896-897, 604/304, 604/307, 128/156
• US Class Current: 424/447
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

Dermal and transdermal patches having a discontinuous pattern printed adhesive layer on a first surface of an active-agent porous membrane, a non-porous backing layer in contact with a second surface of said porous membrane, opposite said first surface so as to define a compartment capable of containing an active agent or formulation thereof therein, an active-agent or formulation thereof within said compartment, and a protective overlayer on said adhesive layer distal to said porous membrane.

Claims

1. In a dermal or transdermal drug delivery system comprising a drug occlusive backing layer, a drug reservoir thereon and a first adhesive to affix (1) said drug reservoir and occlusive backing layer to (2) a patient such that drug contained in said reservoir can be delivered by said system to said patient, and a removable drug occlusive layer on said adhesive, the improvement comprising said first adhesive being in a discrete, discontinuous pattern in a region which, when said patch is applied to said patient, constitutes a reservoir-patient contact area, said first adhesive being present in said region to a degree which results in at least 10% of said region to no more than about 60% of said region having said first adhesive thereon, such that at least 20% of the entire surface area which will contact said patient once said patch is applied to said patient has an adhesive thereon;

said drug being insoluable in said adhesive.

2. The improvement of claim 1 wherein said reservoir-patient contact area having said first adhesive thereon has a continuous border around the perimeter of said first adhesive of a second adhesive.

3. The improvement of claim 2 wherein said second adhesive is different than said first adhesive.

4. The improvement of claim 3 wherein said second adhesive is selected from those in which said drug is readily soluble.

5. The improvement of claim 3 wherein said second adhesive is selected from those in which said drug is insoluble.

6. The improvement of claim 2 wherein said first adhesive and said second adhesive are the same.

7. The improvement of claim 1 wherein at least 20% to about 60% of said region has said first adhesive thereon.

8. The improvement of claim 1 wherein at least about 40% to about 60% of said region has said first adhesive thereon.

9. The improvement of claim 1 wherein about 40% of said region has said first adhesive thereon.

10. The improvement of claim 1 wherein said discontinuous pattern is a series of dots.

11. The improvement of claim 1 wherein said reservoir is a matrix having said drug dispersed therein.

12. The improvement of claim 1 wherein said reservoir is a volume defined by said backing layer and a drug permeable porous membrane fused thereto along the periphery thereof, said drug being contained within said volume so defined.

13. The improved of claim 1 wherein said reservoir is a volume defined by a drug-permeable porous membrane and a secondary membrane, said reservoir being oriented such that when said patch is applied to said patient, said porous membrane is closer to said patient than said secondary membrane, said drug being within said volume so defined.

14. The improvement of claim 1 wherein said discontinuous pattern is a series of crosses.

15. In a dermal or transdermal drug delivery system comprising a drug occlusive backing layer, a drug reservoir thereon and a first adhesive to affix (1) said drug reservoir and occlusive backing layer to (2) a patient such that drug contained in said reservoir can be delivered by said system to said patient, and a removable drug occlusive layer on said adhesive, the improvement comprising said first adhesive being in a discrete, discontinuous pattern in a region which, when said patch is applied to said patient, constitutes a reservoir-patient contact area, said first adhesive being present in said region to a degree which results in at least 10% of said region to no more than about 60% of said region having said first adhesive thereon, such that at least 20% of the entire surface area which will contact said patient once said patch is applied to said patient has an adhesive thereon;

said drug being soluable in said adhesive.

16. The improvement of claim 15 wherein said reservoir-patient contact area having said first adhesive thereon has a continuous border around the perimeter of said first adhesive of a second adhesive.

17. The improvement of claim 16 wherein said first adhesive and said second adhesive are the same.

18. The improvement of claim 15 wherein at least 20% to about 60% of said region has said first adhesive thereon.

19. The improvement of claim 15 wherein at least about 40% to about 60% of said region has said first adhesive thereon.

20. The improvement of claim 15 wherein about 40% of said region has said first adhesive thereon.

21. The improvement of claim 16 wherein said second adhesive is selected from those in which said drug is insoluble.

22. The improvement of claim 15 wherein said discontinuous pattern is a series of dots.

23. The improvement of claim 15 wherein said reservoir is a matrix having said drug dispersed therein.

24. The improvement of claim 15 wherein said reservoir is a volume defined by said backing layer and a drug permeable porous membrane fused thereto along the periphery thereof, said drug being contained within said volume so defined.

25. The improved of claim 15 wherein said reservoir is a volume defined by a drug-permeable porous membrane and a secondary membrane, said reservoir being oriented such that when said patch is applied to said patient, said porous membrane is closer to said patient than said secondary membrane, said drug being within said volume so defined.

26. The improvement of claim 15 wherein said second adhesive is different than said first adhesive.

27. The improvement of claim 15 wherein said second adhesive is selected from those in which said drug is readily soluble.

28. the improvement of claim 15 wherein said discontinuous pattern is a series of crosses.