Composite grafts
First Claim
Patent Images
1. A porous biocompatible composite graft that is resistant to the passage of fluids through its walls, comprising:
- a plurality of layers of biocompatible polymeric fiber material, said fiber layers having been formed by extrusion of a fiber-forming polymer through an orifice to form an elongated fiber that was wound on a mandrel to form a plurality of windings defining said plurality of layers, said plurality of windings defining a non-woven generally porous graft body having overlying fibers that intersect one another to form at least one porous wall of a predetermined thickness that is conducive to tissue ingrowth thereinto;
a generally cylindrical generally non-absorbable non-porous membrane sheath formed in place with respect to the mandrel and at least one of said plurality of layers of the generally porous graft body;
said generally cylindrical generally non-absorbable non-porous membrane sheath was formed in place from a polymeric membrane-forming composition; and
said generally non-absorbable, non-porous membrane sheath is generally interposed between generally consecutive ones of said layers of the generally porous graft body in order to thereby define an internal cylindrical portion of the generally porous graft body and an external cylindrical portion of the generally porous graft body.
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Abstract
Composite grafts are provided that have a porous wall structure to permit ingrowth thereinto under in vivo conditions but which include a generally non-porous membrane in the wall to prevent substantial fluid passage therethrough so as to provide an implantable porous graft that does not require preclotting prior to implantation. One or more of such membranes are formed in place by applying a polymeric membrane-forming composition during the formation of a graft body by winding elongated extruded fibers on a mandrel.
415 Citations
9 Claims
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1. A porous biocompatible composite graft that is resistant to the passage of fluids through its walls, comprising:
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a plurality of layers of biocompatible polymeric fiber material, said fiber layers having been formed by extrusion of a fiber-forming polymer through an orifice to form an elongated fiber that was wound on a mandrel to form a plurality of windings defining said plurality of layers, said plurality of windings defining a non-woven generally porous graft body having overlying fibers that intersect one another to form at least one porous wall of a predetermined thickness that is conducive to tissue ingrowth thereinto; a generally cylindrical generally non-absorbable non-porous membrane sheath formed in place with respect to the mandrel and at least one of said plurality of layers of the generally porous graft body; said generally cylindrical generally non-absorbable non-porous membrane sheath was formed in place from a polymeric membrane-forming composition; and said generally non-absorbable, non-porous membrane sheath is generally interposed between generally consecutive ones of said layers of the generally porous graft body in order to thereby define an internal cylindrical portion of the generally porous graft body and an external cylindrical portion of the generally porous graft body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification