Oxazolidines and compositions containing the same
First Claim
1. Oxazolidines of the formula ##STR10## wherein n is the number 1 or 2,T is lower-carbalkoxy,X is phenoxymethyl or phenyl optionally monosubstituted by fluorine, chlorine, trifluoromethyl or lower-alkoxy,Y is hydrogen or methyl,Z is a group of the formula ##STR11## R1 is lower-alkyl, optionally N-mono-lower-alkylated or N-di-lower-alkylated aminomethyl or a group --C(O)R2, --C(R3)═
- CH--(CH2)m --C(O)R2, --C(H,R3)--(CH2)m+1 --C(O)R2, --C(H,R3)--(CH2)p --OH or --C(R3)═
CH--C(CH3)═
CH--COOCH3,R11 is hydroxy, lower-alkoxy, lower-alkanoyloxy, sulphamoyl, benzyloxy or phenoxy or a group R1, --O--(CH2)q --OH, --O--(CH2)q --COOR4 --O--(CH2)q --O--(CH2)t --R5 or, ##STR12## R2 is hydroxy, lower-alkyl, lower-alkoxy, dimethylaminoethoxy, lower-alkoxycarbonylethyl or optionally mono-lower-alkylated or di-lower-alkylated amino,R3 is hydrogen or methyl,R4 is lower-alkyl,R5 is hydrogen, lower-alkyl or phenyl optionally para-substituted by chlorine, fluorine, trifluoromethyl, lower-alkyl or lower-alkoxy,R6 is lower-alkyl or phenyl optionally para-substituted by fluorine, chlorine, lower-alkyl or lower-alkoxy,m and p are whole numbers of 0 to 6,v is a whole number of 2 to 4,q and t are whole numbers of 1 to 6,and physiologically compatible salts thereof.
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Accused Products
Abstract
The oxazolidines of the formula ##STR1## wherein n signifies the number 1 or 2,
T signifies lower carbalkoxy,
X signifies phenoxymethyl optionally mono-fluorinated or mono-chlorinated in the ortho-position or phenyl optionally monosubstituted by fluorine, chlorine, trifluoromethyl or lower-alkoxy,
Y signifies hydrogen or methyl, and
Z signifies a phenyl or thienyl residue substituted in a defined manner,
and the physiologically compatible salts thereof have catabolic activity and can be used for the treatment of obesity and diabetes mellitus or for the treatment of conditions which are associated with an increased protein breakdown, or as feed additives for fattening animals. They are manufactured starting from corresponding primary amines.
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Citations
16 Claims
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1. Oxazolidines of the formula ##STR10## wherein n is the number 1 or 2,
T is lower-carbalkoxy, X is phenoxymethyl or phenyl optionally monosubstituted by fluorine, chlorine, trifluoromethyl or lower-alkoxy, Y is hydrogen or methyl, Z is a group of the formula ##STR11## R1 is lower-alkyl, optionally N-mono-lower-alkylated or N-di-lower-alkylated aminomethyl or a group --C(O)R2, --C(R3)═ - CH--(CH2)m --C(O)R2, --C(H,R3)--(CH2)m+1 --C(O)R2, --C(H,R3)--(CH2)p --OH or --C(R3)═
CH--C(CH3)═
CH--COOCH3,R11 is hydroxy, lower-alkoxy, lower-alkanoyloxy, sulphamoyl, benzyloxy or phenoxy or a group R1, --O--(CH2)q --OH, --O--(CH2)q --COOR4 --O--(CH2)q --O--(CH2)t --R5 or, ##STR12## R2 is hydroxy, lower-alkyl, lower-alkoxy, dimethylaminoethoxy, lower-alkoxycarbonylethyl or optionally mono-lower-alkylated or di-lower-alkylated amino, R3 is hydrogen or methyl, R4 is lower-alkyl, R5 is hydrogen, lower-alkyl or phenyl optionally para-substituted by chlorine, fluorine, trifluoromethyl, lower-alkyl or lower-alkoxy, R6 is lower-alkyl or phenyl optionally para-substituted by fluorine, chlorine, lower-alkyl or lower-alkoxy, m and p are whole numbers of 0 to 6, v is a whole number of 2 to 4, q and t are whole numbers of 1 to 6, and physiologically compatible salts thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- CH--(CH2)m --C(O)R2, --C(H,R3)--(CH2)m+1 --C(O)R2, --C(H,R3)--(CH2)p --OH or --C(R3)═
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14. An animal feed composition comprising feed to which there is admixed a suitable quantity of a compound of the formula ##STR13## wherein n is the number 1 or 2,
T is lower-carbalkoxy, X is phenoxymethyl or phenyl optionally monosubstituted by fluorine, chlorine, trifluoromethyl or lower-alkoxy, Y is hydrogen or methyl, Z is a group of the formula ##STR14## R1 is lower-alkyl, optionally N-mono-lower-alkylated or N-di-lower-alkylated aminomethyl or a group --C(O)R2, --C(R3)═ - CH--(CH2)m --C(O)R2, --C(H,R3)--(CH2)m+1 --C(O)R2, --C(H,R3)--(CH2)p --OH or --C(R3)═
CH--C(CH3)═
CH--COOCH3,R11 is hydroxy, lower-alkoxy, lower-alkanoyloxy, sulphamoyl, benzyloxy or phenoxy or a group R1, --O--(CH2)q --OH, --O--(CH2)q 13 COOR4 --O--(CH2)q --O--(CH2)t --R5 or, ##STR15## R2 is hydroxy, lower-alkyl, lower-alkoxy, dimethylaminoethoxy, lower-alkoxycarbonylethyl or optionally mono-lower-alkylated or di-lower-alkylated amino, R3 is hydrogen or methyl, R4 is lower-alkyl, R5 is hydrogen, lower-alkyl or phenyl optionally para-substituted by chlorine, fluroine, trifluoromethyl, lower-alkyl or lower-alkoxy, R6 is lower-alkyl or phenyl optionally para-substituted by fluorine, chlorine, lower-alkyl or lower-alkoxy, m and p are whole numbers of 0 to 6, v is a whole number of 2 to 4, q and t are whole numbers of 1 to 6, or a physiologically compatible salt thereof. - View Dependent Claims (15, 16)
- CH--(CH2)m --C(O)R2, --C(H,R3)--(CH2)m+1 --C(O)R2, --C(H,R3)--(CH2)p --OH or --C(R3)═
Specification