Two-phase compositions for absorbable surgical devices
First Claim
1. An absorbable, annealed surgical device of a multi-phase polymeric composition derived from lactide and glycolide, the first phase having about 0-about 25% m glycolide moieties and about 75-about 100% m lactide moieties and the other phase or phases having glycolide and lactide moieties in amounts such that the composition overall has up to 45% m glycolide moieties, wherein the first phase constitutes at least 50% by weight of the annealed surgical device.
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Abstract
An absorbable, annealed surgical device made from a multi-phase, polymeric composition derived from lactide and glycolide is disclosed. Preferably, the composition has two phases, both phases are continuous, the first phase has about 0-about 25% m glycolide moieties, the overall composition has up to 45% m glycolide moieties, and the first phase constitute at least 50% (and preferably not more than about 95%) by weight of the composition. The device has a high distortion temperature, good resistance to hot-wet creep, but yet loses tensile strength in vivo quickly. The composition per se is injection-moldable, can be annealed, and is not brittle.
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Citations
28 Claims
- 1. An absorbable, annealed surgical device of a multi-phase polymeric composition derived from lactide and glycolide, the first phase having about 0-about 25% m glycolide moieties and about 75-about 100% m lactide moieties and the other phase or phases having glycolide and lactide moieties in amounts such that the composition overall has up to 45% m glycolide moieties, wherein the first phase constitutes at least 50% by weight of the annealed surgical device.
- 10. An annealable, injection-moldable lactide/glycolide polymeric composition having at least two phases wherein the first phase contains about 0-about 25% m glycolide moieties and about 75-about 100% m lactide moieties and the other phase or phases contain glycolide moieties in amounts such that the overall composition contains up to 45% m glycolide moieties, wherein the first phase constitutes at least 50% by weight of the annealable polymeric composition.
- 23. An absorbable, injection moldable multi-phase polymeric composition containing lactide and glycolide moieties, comprising a matrix polymer phase and a discrete polymer phase dispersed therein, the matrix phase comprising a polymer composition which is lactide-rich and the discrete phase comprising a polymer composition which is glycolide-rich and having a melting point which is higher than the melting point of the lactide-rich phase, and the multi-phase polymer composition as a whole comprising predominantly lactide moieties.
- 26. An absorbable, annealed surgical device of multi-phase polymeric composition containing lactide and glycolide moieties, comprising a matrix polymer phase and a discrete polymer phase dispersed therein, the matrix phase comprising a polymer composition which is lactide-rich and the discrete phase comprising a polymer composition which is glycolide-rich and having a melting point which is higher than the melting point of the lactide-rich phase, and the multi-phase polymer composition as a whole comprising predominantly lactide moieties.
Specification