Iontophoretic drug delivery
First Claim
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1. An improved method of iontophoretic drug delivery wherein an electrochemically active component of either the anode or the cathode of the iontophoresis device is intentionally comprised of a material that effets oxidation/reduction without being consumed to produce a species which interacts with an intentionally selected drug in which a corresponding weak acid/weak base form is selected to be delivered, so that water hydrolysis products are minimized.
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Abstract
Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
170 Citations
6 Claims
- 1. An improved method of iontophoretic drug delivery wherein an electrochemically active component of either the anode or the cathode of the iontophoresis device is intentionally comprised of a material that effets oxidation/reduction without being consumed to produce a species which interacts with an intentionally selected drug in which a corresponding weak acid/weak base form is selected to be delivered, so that water hydrolysis products are minimized.
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Current AssigneeALZA Corporation (Johnson & Johnson)
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Original AssigneeMedtronic Incorporated (Medtronic Plc)
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InventorsPhipps, Joseph B., Untereker, Darrel F.
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Primary Examiner(s)Kight, John
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Assistant Examiner(s)Morgan, Kriellion
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Application NumberUS06/665,699Time in Patent Office1,310 DaysField of Search128/783, 128/798, 128/803, 604/20, 604/21US Class Current604/20CPC Class CodesA61N 1/0436 Material of the electrodeA61N 1/0444 MembraneA61N 1/0448 Drug reservoir
