Apparatus and methodology for pulsed administration of growth promoting agents
First Claim
1. A method of therapeutically effective treatment of a living animal comprising administering to the animal a dynamic dosage of growth hormone releasing factor, analogs, biologically active fragments and derivatives thereof (collectively GRF) said dynamic dosage comprising administration of GRF to be interrupted by periods of non-administration of GFR of from at least about 2 times the half-life of GRF in the blood.
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Abstract
A method and apparatus for therapeutically effective treatment of a living animal comprising administering a dynamic dosage of growth hormone releasing factor or analog thereof, or administering growth hormone or analogs thereof in a chronic course of treatment in a subdesensitizing regimen. Also a method of diagnosing living animals with an anterior pituitary unresponsive to growth hormone releasing factor or analogs thereof. A method of determining the optimum GRF and GH dynamic dosage for a given living animal, particularly a human.
33 Citations
30 Claims
- 1. A method of therapeutically effective treatment of a living animal comprising administering to the animal a dynamic dosage of growth hormone releasing factor, analogs, biologically active fragments and derivatives thereof (collectively GRF) said dynamic dosage comprising administration of GRF to be interrupted by periods of non-administration of GFR of from at least about 2 times the half-life of GRF in the blood.
- 10. A method of therapeutically effective treatment of a living animal comprising administering to the animal a dynamic dosage of growth hormone releasing factor, analogs, biologically active fragments and derivatives thereof (collectively GRF) said dynamic dosage comprising administration of GRF from about every half hour to about every 5 hours.
- 25. A method of therapeutically effective treatment of a living animal comprising administering to the animal a dynamic dosage of growth hormone, analogs, biologically active fragments and derivatives thereof (collectively GH) said dynamic dosage comprising administration of GH to be interrupted by periods of non-administration of GH of from at least about two times the half-life of GH in the blood.
- 28. A method of therapeutically effective treatment of a living animal comprising administering to the animal a dynamic dosage of growth hormone, analogs, biologically active fragments and derivatives thereof (collectively GH) said dynamic dosage comprising administration of GH about every half hour to about every 5 hours.
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30. A method of diagnosing in a living animal growth retardation due to the inability of the pituitary to respond to a dynamic dosage of growth hormone releasing factor, analogs, biologically active fragments and derivatives thereof (collectively GRF) wherein the dynamic dosage of GRF comprises administration of GRF from about every half hour to about every 5 hours the method comprising administering said dynamic dosage and measuring the response thereto.
Specification