×

Synthetic resin matrix system for the extended delivery of drugs

  • US 4,747,845 A
  • Filed: 01/03/1986
  • Issued: 05/31/1988
  • Est. Priority Date: 10/17/1983
  • Status: Expired due to Fees
First Claim
Patent Images

1. A synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, an inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer, said polymer selected from the group consisting of hydroxy(C2 -C4 -alkyl) methacrylate, hydroxy(C2 -C4 alkyl) acrylate, hydroxy(C2 -C4 alkoxyC2 -C4 alkyl) methacrylate, hydroxy(C2 -C4 alkoxyC2 -C4 alkyl) acrylate, alkoxy(C2 -C4 alkoxyC2 -C4 alkyl) methacrylate, alkoxy(C2 -C4 alkoxyC2 -C4 alkyl) acrylate, N-(C1 -C4 alkyl) acrylamide, N-(C1 -C4 alkyl) methacrylamide, N,N-di(C1 -C4 alkyl) acrylamide, N,N-di(C1 -C4 alkyl) methacrylamide, vicinal-epoxy(C1 -C4 alkyl) methacrylate, or vicinal-epoxy(C1 -C4 alkyl) acrylate, said solvent selected from the group consisting of polyethylene glycol or polypropolene glycol having a molecular weight averaging between about 200-2000 gram molecules weight units, and wherein said plasticizer being selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, or butyrolactone, with said polymer ranging between about 15%-50% by weight of said matrix system, with said solvent ranging between about 30%-65% by weight of said matrix system, and with said plasticizer ranging up to about 20% by weight of said matrix system.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×