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System for delivering potassium chloride with enhanced bioacceptability

  • US 4,747,847 A
  • Filed: 07/09/1987
  • Issued: 05/31/1988
  • Est. Priority Date: 02/07/1986
  • Status: Expired due to Term
First Claim
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1. A dosage form for delivering a beneficial drug to a fluid biological environment for use, the dosage form comprising:

  • (a) a wall comprising in at least a part a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of drug, which wall surrounds and forms;

    (b) a compartment housing a composition comprising (1) a therapeutically effective dose of the beneficial drug potassium chloride blended with (2) means for aiding in delivering the potassium chloride from the compartment and for lessening the incidence of unwanted side effects of potassium chloride on the bioloical environment of use, said means comprising a first hydrogel and a different second hydrogel;

    (c) at least one passageway in the wall communicating with the compartment and the exterior of the dosage form for delivering the composition comprising the potassium chloride and the means from the dosage form over a prolonged period of time; and

    ,(d) wherein, when the dosage form is in operation in the environment of use, the dosage form delivers the composition comprising the potassium chloride and the means comprising the first and second hydrogels for the potassium chloride therapeutic effects and for simultaneously lessening the incidence of unwatned side effects on the environment of use.

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