Test strip for collecting of blood sugar daily profiles and process for its preparation
First Claim
1. A test strip for receiving blood sugar daily profiles, comprising a carrier, a film forming membrane, and an enzyme indicator reaction layer disposed on said membrane, said reaction layer containing glucose oxidase, peroxidase, and o-tolidine, said reaction layer being treated with from about 0.01 to about 0.1 mole of a chelating agent and with from about 0.01 to about 1 mole of choline, amino-trihydroxymethylmethane, collidine, quinoline or quinoazine.
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Abstract
The invention relates to a test strip for taking of daily blood sugar profiles, and also for glucose determination in urine for determining the individual kidney threshold of a diabetic as a daily profile, which finds use in glucose diagnosis.
The objective of the invention is to stabilize the test strip in its function and to adapt it to customary measuring instruments, and this is achieved by attaching a film reaction membrane to a carrier, wherein the membrane was post treated with a complexing agent and an acyclic hydroxyamine or amino derivative.
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Citations
23 Claims
- 1. A test strip for receiving blood sugar daily profiles, comprising a carrier, a film forming membrane, and an enzyme indicator reaction layer disposed on said membrane, said reaction layer containing glucose oxidase, peroxidase, and o-tolidine, said reaction layer being treated with from about 0.01 to about 0.1 mole of a chelating agent and with from about 0.01 to about 1 mole of choline, amino-trihydroxymethylmethane, collidine, quinoline or quinoazine.
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14. A process for preparing a test strip for receiving blood sugar daily profiles, comprising a carrier, a film forming membrane, and an enzyme indicator reaction layer disposed on said film forming membrane, said enzyme indicator reaction layer containing glucose oxidase, peroxidase, and o-tolidine, the process comprising the steps of:
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(a) applying the film forming membrane to the enzyme indicator reaction layer, (b) swelling the indicator reaction layer with from about 0.01 to about 0.1 mole of a chelating agent and from 0.01 to about 1 mole of choline, amino-trishydroxymethylmethane, collidine, quinoline, or piperazin, (c) treating the reaction layer with additional amounts of said chelating agent and choline, amino-trishydroxymethylmethane, collidine, quinoline or piperazin, and (d) applying the layered film forming membrane to the carrier. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification