Alkyl glycosides as potentiating agents in antiseptic, disinfecting and cleaning preparations to increase microbicidal activity

• US 4,748,158 A
• Filed: 12/06/1985
• Issued: 05/31/1988
• Est. Priority Date: 12/10/1984
• Status: Expired due to Term

• Current Assignee: Henkel KGaA (Henkel AG & Co KGaA)
• Original Assignee: Henkel KGaA (Henkel AG & Co KGaA)
• Inventors: Schmid, Karl-Heinz, Biermann, Manfred, Lehmann, Rudolf, Ploeger, Walter, Klueppel, Hans-Juergen, Schnegelberger, Harald
• Primary Examiner(s): Brown, J. R.
• Assistant Examiner(s): Peselev, Elli
• Application Number:
  US06/806,059
• Time in Patent Office: 907 Days
• Field of Search: 514/25, 514/635, 514/49, 536/4.1, 536/16.8
• US Class Current: 514/25
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/604 Alkylpolyglycosides; Derivatives thereof, e.g. esters
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

Alkyl glycosides are used to greatly increase the microbicidal activity of biguanide compounds, such as chlorhexidine salts. The alkyl glycoside/biguanide agents have a particular utility in teeth cleaning preparations due to their improved microbicidal activity against gram-positive bacteria.

Claims

1. A microbiocidal composition comprising a microbiocidally-active combination of a biguanide compound microbiocidally active against bacteria and from about 10 to about 10,000 ppm of a C₆ - C₁₈ -alkyl glycoside in a non-microbiocidally-active amount which is sufficient to potentiate the microbiocidal activity of said biguanide.

2. The composition as defined in claim 1, wherein the biguanide compound comprises a chlorhexidine salt.

3. The composition as defined in claim 1, wherein the amount of alkyl glycoside is in the range of about 10-2000 ppm.

4. The composition as defined in claim 1, wherein the amount of alkyl glycoside is in the range of about 50-1000 ppm.

5. The compositon as defined in claim 1, wherein the alkyl glycoside and the biguanide compound are present in substantially the same quantities by weight.

6. The composition as defined in claim 1, wherein the alkyl glycoside contains an alkyl group having from about 8 to 16 carbon atoms.

7. The composition as defined in claim 6, wherein the alkyl group contains from about 10 to 14 carbon atoms.

8. The composition as defined in claim 1, wherein the alkyl glycoside comprises a monoglycoside.

9. The composition as defined in claim 1, wherein the alkyl glycoside comprises an oligoglycoside.

10. The composition as defined in claim 9, wherein the oligoglycoside contains up to 8 glycoside residues.

11. The composition as defined in claim 9, wherein the oligoglycoside contains up to 3 glycoside residues.

12. A surface disinfection composition including the microbiocidal composition of claim 1.

13. A hygienic composition for the care of the oral cavity comprising a physiologically-compatible carrier and the microbiocidal composition of claim 1 in a microbiocidally-active amount.

14. The hygienic composition of claim 13, further including an abrasive tooth polish compatible with the biguanide compound.

15. The hygienic composition of claim 13, wherein the carrier comprises a solution of alcohol in water.

16. The hygienic composition of claim 13, further including a binder.

17. The hygienic composition of claim 13, wherein the microbiocidal composition comprises a biguanide compound present in a amount insufficient for substantial microbiocidal activity, and the C₆ -C₁₈ - alkyl glycoside is present in an amount sufficient to potentiate the microbiocidal activity of the biguanide compound and microbiocially-activate the microbiocidal composition.

18. The hydienic composition of claim 17, further including an abrasive tooth polish compatible with the biguanide compound.

19. The hygienic composition of claim 13, wherein the bacteria are gram-positive bacteria.

20. The hygienic composition of claim 13, wherein the alkyl glycoside is present in an amount sufficient to further function as a foaming agent.

21. The composition of claim 1, wherein the alkyl glycoside is the reaction product of a fatty alcohol and a sugar.

22. The composition of claim 1, wherein the alkyl portion of the glycoside contains an even number of carbon atoms.

23. A method for improving the hygiene of the oral cavity comprising contacting the cavity with a hygienic composition according to claim 13.

24. The method of claim 23, wherein the bacteria are gram-positive bacteria.

25. The method of claim 24, wherein the microbicidally-active

26. The method of claim 24, wherein the microbiocidally-active composition is a tooth powder.

27. The method of claim 24, wherein the microbiocidally-active composition is a mouthwash.

28. The method of claim 23, wherein the biguanide compound is present in an amount insufficient for substantial microbiocidal activity in the oral cavity and the C₆ -C₁₈ -alkyl glycoside is present in an amount sufficient to potentiate the microbiocidal activity of the biguanide compound and to microbiocidally activate the composition.